11 Day American Cruise Lines River Cruise from New Orleans to Louisville 2026

Day 1 New Orleans, LA

In New Orleans, time stretches like molasses, urging you to linger a little longer in its enchanting embrace. Board a streetcar bound for the Garden District, a verdant oasis where mansions adorned with intricate ironwork stand as silent witnesses to the passage of time. Immerse yourself in the narratives of courage and sacrifice at the National World War II Museum, where the echoes of heroism reverberate through the halls.

Day 2 Cruising the Mississippi River

Board your ship, get settled in, and ready for the adventure ahead. We’ll start with a welcome reception and toast to you, our crew, and all the excitement we have on the horizon. As we set sail, watch the Mississippi begin to bend and wave goodbye to the Big Easy.

Day 3 Baton Rouge, LA

Baton Rouge, named "red stick" in 1699 by the French, nods to a historical landmark and embodies a legacy spanning centuries. As Louisiana's seat of government, the city resonates with narratives of notable figures, notably Governor and Senator Huey P. Long. Learn more about the gripping saga of his career at the magnificent 1852 Old State Capitol Museum, where the past is vividly portrayed. Then, stand in awe of Long's enduring influence with a tour of the striking 1932 State Capitol building, a marvel of granite and marble craftsmanship.

Wander through the storied neighborhoods, each exuding its own distinct charm and allure. Don’t miss out on a narrated boat journey through the captivating Louisiana swamps, where secrets and stories wait amidst the thick foliage and meandering waterways.

Day 4 Natchez, MS

In Natchez, like radiant gems, magnificent homes grace the bluffs overlooking the river. Since 1716, when the French erected the initial fort amidst the Natchez Indians, the town has thrived, showcasing lavish mansions built by planters in the 1800s to display their wealth. Despite the absence of Civil War skirmishes, Natchez boasts numerous pre-Civil War homes and structures. Each architectural marvel holds its own tale, contributing to a charming downtown that embodies the essence of Southern hospitality and grace.

Forge your path or join meticulously curated guided experiences. Explore the intricate townhouses, delve into the history and significance of cotton farming at a working farm, and uncover the historic charm of the Under-The-Hill Saloon. Meander through quaint boutiques, sample local delicacies, and relish the sweeping views of the majestic river valley from the bluff-top park.

Day 5 Vicksburg, MS

Amidst the Civil War, the battle for control over Vicksburg emerged as a pivotal turning point. Dubbed “The Gibraltar of the West,” its formidable defenses, strategically positioned between river and rail transportation, posed a challenge. Join a narrated journey through the meticulously preserved National Military Park battlefield, where history comes to life.

President Abraham Lincoln's words underscored Vicksburg's strategic importance: “Vicksburg is the key. The war can never be brought to a close until that key is in our pocket… They can defy us from Vicksburg… As valuable as New Orleans will be to us, Vicksburg will be more so.”

Step aboard a colossal Army Corps of Engineers towboat, immersing yourself in the engineering marvels that shaped the region. Wander along the delightful series of murals adorning the adjacent floodwall, each panel intricately detailing the extent of Vicksburg's history.

Day 6 Day of River Cruising

Today we cruise from the history found in Vicksburg to the rhythm and blues of Memphis. Along the way, watch the Mississippi move from thick forest to sandy beaches. From quaint riverbank towns to big cities, all humming the same tune. Sit on the sun deck, relax, read, and recharge for more adventures ahead. Share stories of the day and the days to come with new friends in our comfortable lounge, relax on the sun deck, and don’t miss cocktail hour before enjoying a delicious dinner with a menu of local dishes.

Day 7 Memphis, TN

Welcome to lively Memphis, a city entrenched in history and brimming with energy. From the days of the Civil War to the triumphant strides of the Civil Rights Movement, you can feel the city's heartbeat as you become a part of its legendary legacy. Stroll along the revered grounds of Beale Street, where every note carries the feeling of Memphis, and the air is alive with the rhythm of blues and jazz. Be sure to taste some classic, tangy Memphis BBQ while you’re here.

Join us on a variety of engaging excursions. Opt for a narrated motorcoach tour to gain a panoramic view of this dynamic city, absorbing its atmosphere and historic landmarks. Explore the life and legacy of the King of Rock 'n' Roll with a visit to Elvis Presley's home, Graceland, a pilgrimage revered by fans worldwide. Alternatively, venture to the iconic Sun Studio, where Elvis's earliest recordings still reverberate through the walls, immortalizing his legendary career.

As your day of exploration draws to a close, return to the comfort of your awaiting ship at the Beale Street Landing, situated within a recently revitalized city park. Be serenaded by local musicians onboard as you enjoy a nightcap, reflecting on the day's adventures and eagerly anticipating the journey that lies ahead.

Day 8 Day of Cruising

Today, let's celebrate the journey as much as the destinations themselves. Embrace picturesque landscapes along the iconic Mississippi River. Take pleasure in the unspoiled stretches of land, the quaint charm of riverside towns, and the majestic presence of wildlife.

As we glide along the river's gentle currents, take in the expert commentary from our onboard naturalist, who will regale you with tales of the native wildlife that call this region home. Alternatively, find solace in simply basking in the warmth of the sun on the bow, allowing the soothing rhythm of the river to lull you into a state of serene contentment.

Day 9 Paducah, KY

At the meeting point of the Tennessee River and the Ohio River lies Paducah, inviting you on a journey through time. Walk the cobblestone streets of this historic Chickasaw village site, where each corner tells a story of Paducah’s past. Explore the Wall-to-Wall Mural Program, showcasing over 50 murals depicting Native American history, pivotal Civil War events, and local landmarks like the Old Carnegie Library, rendered in vivid detail.

With the guidance of our seasoned local expert, delve deeper into Paducah's history. Uncover hidden stories and lesser-known corners of the city. No exploration of Paducah would be complete without a visit to the renowned National Quilt Museum, where the intricate artistry and cultural significance of quilting come to life through stunning exhibits.

Day 10 Day of River Cruising

Relax and savor the soothing melody of the paddlewheel as it churns through the calm waters of the Ohio River. A true highlight of this voyage lies in the opportunity to witness the ever-shifting panorama of scenery unfolding along the riverbanks, offering a glimpse into the untouched beauty of the landscape as early explorers once beheld centuries ago.

Day 11 St. Louis, MO

St. Louis proudly wears the title of the “Gateway to the West,” and it’s easy to see why. Feast your eyes on the breathtaking riverfront, dominated by the iconic Gateway Arch, an engineering marvel and the tallest man-made monument in the United States.

Prepare to be dazzled by St. Louis’ abundance of world-class attractions. Experience the art at the renowned Saint Louis Art Museum, where masterpieces from around the globe await your discovery. Feed your curiosity at the Science Center, where hands-on exhibits and interactive displays ignite a passion for exploration. Then, follow a tour of the historic Anheuser-Busch Brewery, where the art of brewing meets over a century of tradition. And don’t forget to learn more about the captivating tales of Missouri’s past at the Missouri History Museum, where history comes to life through engaging exhibits and immersive experiences.

Day 12 St. Louis, MO

Conclude your voyage in this extraordinary city, where frontier-town roots blend seamlessly with Midwest modesty. As you bid farewell, take a moment to reflect on the multitude of unforgettable experiences you've had along the way. Whether you choose to reminisce about your fantastic adventures or opt to extend your stay and explore further in the Gateway to the West, let the spirit of St. Louis linger as you journey homeward.