11 Day American Cruise Lines River Cruise from Pittsburgh to St. Louis 2022

American Cruise Lines River Cruise - Pittsburgh to St. Louis

Ohio River Cruise

Starting from $5,415
Ship(s): American Heritage
American Cruise Lines
11 Day American Cruise Lines River Cruise from Pittsburgh to St. Louis 2022

River Cruise Description

Experience two of America’s greatest rivers on this 11-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain. The Ohio River was pivotal in the development and exploration of the American West and along the way we highlight much that has defined our American roots from the Civil War to bluegrass music. Or, you can take a milder pace and just kick back with a rocking chair and a glass of sweet tea on the sun deck while American Cruise Lines handles the rest. 

Each port of call showcases a new element of Americana. In Henderson, for instance, you may visit the John James Audubon Museum, which features many original works and join our expert guide to learn about the sense of natural wonder that Audubon instilled in so many Americans. While in Louisville, we are treated to a behind the scenes tour of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery, each destination with a distinct American story to tell. 

Every cruise on the Ohio River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and, as it has been since the dawn of river travel, our sailing schedules must adapt to it. It is possible that guests will be transported between a town on the Ohio River and Pittsburgh by coach for excursions or embarkation. 

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Departure DateShipPriced From
(per person)
Aug 16, 2022American Heritage$5,415Call Us!
Sep 5, 2022American Heritage$5,810Call Us!
Sep 25, 2022American Heritage$5,810Call Us!

River Cruise Itinerary

Day 1 Pittsburgh, PA

Begin your journey in the "steel city," Pittsburgh, PA. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce making it a wealthy town in the 18th and 19th centuries. As you cruise the Ohio River delight in picturesque and ever-changing scenery, as early explorers did centuries ago.

Day 2 Marietta, OH

The second-largest city in the Parkersburg-Marietta-Vienna Metropolitan area, Marietta was named in honor of Marie Antoinette. During the 18th and 19th century, the town experienced economic prosperity, as its location on the Ohio River made it an attractive stop for commercial steamboats, as well as travelers.

Day 3 Maysville, KY

Maysville is a quaint town with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original bluegrass country music.

Day 4 Cincinnati, OH

Enjoy a visit to Cincinnati, a vibrant city and cultural center which boasts two major sports franchises, a zoo and botanical garden, and numerous theaters and museums. Stroll along its picturesque streets, abounding in eclectic architecture and shop at the famous Findlay Market, a longtime gathering place for vendors to sell local goods, meats, and fresh produce.

Day 5 Louisville, KY

Day 6 Louisville, KY

Spend another day in Kentucky, known as the "Bluegrass State," due to the bluegrass found in many of its pastures because of the fertile soil. On the Louisville Downtown Shuttle, explore the Old Louisville neighborhood, the largest historic preservation district in the U.S., solely featuring Victorian homes and buildings.

Day 7 Henderson, KY

You won’t miss the presence of the notable resident, John James Audubon, whose “Birds of America” paintings are recreated as bronze statues throughout Henderson. Named after President Washington’s home on the Potomac, this bucolic river town is steeped in fascinating lore. Let our expert guide lead you on a tour of our famous first President's historic home and grounds.

Day 8 Paducah, KY

Residing at the confluence of the Tennessee River and the Ohio River, Paducah will makeyou feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library.

Day 9 Cape Girardeau, MO

Explore the history and culture of the "City of Roses".

Day 10 St. Louis, MO

St. Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, and the Missouri History Museum. End your day at the Missouri Botanical Garden, one of the world’s most popular public gardens.

Day 11 St. Louis, MO

End your journey in this unique city with frontier-town roots and Midwest modesty. On your travels home, reflect upon your many wonderful adventures, or choose to explore more in the Gateway to the West.
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