14 Day American Cruise Lines River Cruise from New Orleans to Louisville 2027

Day 1 New Orleans, LA

Welcome to New Orleans, celebrated globally for its endless nightlife, live music, and distinctive cuisine that mirrors its background as a blend of French, African, and American cultures. This lively city is an ideal starting point for your historic river journey. Check into your hotel and prepare for an enchanting exploration of this city. Wander down avenues shaded by trees, enjoy a carriage tour through the French Quarter, ride a streetcar to the beautiful Garden District, or explore the famous National World War II Museum.

Every Mississippi itinerary includes a Hotel Stay, ensuring a smooth transition to boarding the ship and exploring the surrounding locale. On the cruise's morning, gather in the hotel lobby, and we will take you to the ship to start your cruise. All your bags will be transferred directly from the hotel and placed in your cabin aboard the ship, making the beginning of your river experience seamless and worry-free.

Day 2 Cruising the Mississippi River

Board your ship, get settled in, and ready for the adventure ahead. We’ll start with a welcome reception and toast to you, our crew, and all the excitement we have on the horizon. As we set sail, watch the Mississippi begin to bend and wave goodbye to the Big Easy.

Day 3 Oak Alley, LA

This iconic Southern estate is renowned for its oak-lined avenue, stretching majestically towards the Mississippi River. Built in the early 19th century, this Greek Revival mansion exudes charm with its grand architecture and lush gardens. Visitors are transported back in time as they explore the meticulously preserved interiors and learn about the land’s history, including its role in the sugar industry.

Enjoy an afternoon narrated boat ride through the Manchac Swamp, a privately owned wildlife refuge. Relax on a covered, comfortable boat with plenty of room to move and clear views from every seat. Swamp wildlife—especially the “jumping gators”—often come within a few feet, responding to the captain’s call. Keep an eye out for nutria, ibis, turtles, herons, raccoons, egrets, and more.

Day 4 Baton Rouge, LA

Baton Rouge, named "red stick" in 1699 by the French, nods to a historical landmark and embodies a legacy spanning centuries. As Louisiana's seat of government, the city resonates with narratives of notable figures, notably Governor and Senator Huey P. Long. Learn more about the gripping saga of his career at the magnificent 1852 Old State Capitol Museum, where the past is vividly portrayed. Then, stand in awe of Long's enduring influence with a tour of the striking 1932 State Capitol building, a marvel of granite and marble craftsmanship.

Wander through the storied neighborhoods, each exuding its own distinct charm and allure. Don’t miss out on a narrated boat journey through the captivating Louisiana swamps, where secrets and stories wait amidst the thick woods and meandering waterways.

Day 5 Day of River Cruising

Today is your day to unwind and take it all in. Glide effortlessly along the Mighty Mississippi, surrounded by breathtaking panoramas of cottonwood trees and graceful blue herons.

Engage in captivating enrichment sessions and lively onboard events. Delight in gourmet cuisine and refreshing cocktails. Whether you're lounging in our spacious lounges or basking in the sun on the deck, there's endless fun to be had. As Mark Twain famously said, it's a day with "nothing to hang a worry or a fret upon" – so let go and embrace the adventure.

Day 6 Natchez, MS

In Natchez, like radiant gems, magnificent homes grace the bluffs overlooking the river. Since 1716, when the French erected the initial fort amidst the Natchez Indians, the town has thrived, showcasing lavish mansions built by planters in the 1800s to display their wealth. Despite the absence of Civil War skirmishes, Natchez boasts numerous pre-Civil War homes and structures. Each architectural marvel holds its own tale, contributing to a charming downtown that embodies the essence of Southern hospitality and grace.

Forge your path or join meticulously curated guided experiences. Explore the intricate townhouses, delve into the history and significance of cotton farming at a working farm, and uncover the historic charm of the Under-The-Hill Saloon. Meander through quaint boutiques, sample local delicacies, and relish the sweeping views of the majestic river valley from the bluff-top park.

Day 7 Vicksburg, MS

Amidst the Civil War, the battle for control over Vicksburg emerged as a pivotal turning point. Dubbed “The Gibraltar of the West,” its formidable defenses, strategically positioned between river and rail transportation, posed a challenge. Join a narrated journey through the meticulously preserved National Military Park battlefield, where history comes to life.

President Abraham Lincoln's words underscored Vicksburg's strategic importance: “Vicksburg is the key. The war can never be brought to a close until that key is in our pocket… They can defy us from Vicksburg… As valuable as New Orleans will be to us, Vicksburg will be more so.”

Step aboard a colossal Army Corps of Engineers towboat, immersing yourself in the engineering marvels that shaped the region. Wander along the delightful series of murals adorning the adjacent floodwall, each panel intricately detailing the extent of Vicksburg's history.

Day 8 Day of River Cruising

Today we cruise from the history found in Vicksburg to the rhythm and blues of Memphis. Along the way, watch the Mississippi move from thick forest to sandy beaches. Sit on the sun deck, relax, read, and recharge for more adventures ahead. Share stories of the day and the days to come with new friends in our comfortable lounge, relax on the sun deck, and don’t miss cocktail hour before enjoying a delicious dinner with a menu of local dishes.

Day 9 Memphis, TN

Welcome to lively Memphis, a city entrenched in history and brimming with energy. From the days of the Civil War to the triumphant strides of the Civil Rights Movement, you can feel the city's heartbeat as you become a part of its legendary legacy. Stroll along the revered grounds of Beale Street, where every note carries the feeling of Memphis, and the air is alive with the rhythm of blues and jazz. Be sure to taste some classic, tangy Memphis BBQ while you’re here.

Join us on a variety of engaging excursions. Opt for a narrated motorcoach tour to gain a panoramic view of this dynamic city, absorbing its atmosphere and historic landmarks. Explore the life and legacy of the King of Rock 'n' Roll with a visit to Elvis Presley's home, Graceland, a pilgrimage revered by fans worldwide. Alternatively, venture to the iconic Sun Studio, where Elvis's earliest recordings still reverberate through the walls, immortalizing his legendary career.

As your day of exploration draws to a close, return to the comfort of your awaiting ship at the Beale Street Landing, situated within a recently revitalized city park. Be serenaded by local musicians onboard as you enjoy a nightcap, reflecting on the day's adventures and eagerly anticipating the journey that lies ahead.

Day 10 Day of Cruising

Today, let's celebrate the journey as much as the destinations themselves. Embrace picturesque landscapes along the iconic Mississippi River. Take pleasure in the unspoiled stretches of land, the quaint charm of riverside towns, and the majestic presence of wildlife.

As we glide along the river's gentle currents, take in the expert commentary from our onboard naturalist, who will regale you with tales of the native wildlife that call this region home. Alternatively, find solace in simply basking in the warmth of the sun on the bow, allowing the soothing rhythm of the river to lull you into a state of serene contentment.

Day 11 Paducah, KY

At the meeting point of the Tennessee River and the Ohio River lies Paducah, inviting you on a journey through time. Walk the cobblestone streets of this historic Chickasaw village site, where each corner tells a story of Paducah’s past. Explore the Wall-to-Wall Mural Program, showcasing over 50 murals depicting Native American history, pivotal Civil War events, and local landmarks like the Old Carnegie Library, rendered in vivid detail.

With the guidance of our seasoned local expert, delve deeper into Paducah's history. Uncover hidden stories and lesser-known corners of the city. No exploration of Paducah would be complete without a visit to the renowned National Quilt Museum, where the intricate artistry and cultural significance of quilting come to life through stunning exhibits.

Day 12 Day of River Cruising

Relax and savor the soothing melody of the paddlewheel as it churns through the calm waters of the Ohio River. A true highlight of this voyage lies in the opportunity to witness the ever-shifting panorama of scenery unfolding along the riverbanks, offering a glimpse into the untouched beauty of the landscape as early explorers once beheld centuries ago.

Day 13 Huntsville, AL

Huntsville, Alabama, blends Southern charm with high-tech innovation, earning its nickname “Rocket City” for its pivotal role in space exploration.

Visit the U.S. Space & Rocket Center which showcases the history and achievements of America’s space program, featuring rockets, spacecraft, and interactive exhibits. Here, you can recount the first time you heard "That's one small step for a man, one giant leap for mankind!"

Step back in time as you explore nearby Mooresville, the entire town which is on the National Register of Historic Places. Explore the onsite 1818 farms, where you can take part in a hands-on pressed-flower workshop, see a demonstration of a natural dyeing eco printing process, and stroll through a flower field.

Day 14 Huntsville, AL

End your journey in this dynamic city known for its deep ties to space exploration and technology. After breakfast on board, we say goodbye and transport you to the airport for your journey homeward. Take a moment to reflect on the journeys you've taken, the meaningful memories you've made, and the lasting connections that continue to shape your path.