15 Day American Cruise Lines River Cruise from New Orleans to St. Paul 2022

American Cruise Lines River Cruise - New Orleans to St. Paul

Grand Heartland Cruise

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American Cruise Lines
15 Day American Cruise Lines River Cruise from New Orleans to St. Paul 2022

River Cruise Description

Enjoy an epic 15-day journey on our Grand Heartland Cruise. This cruise on the Mississippi River travels from the northern reaches of St. Paul all the way down to the basin in New Orleans.

View the dramatic landscapes of the Upper Mississippi River which have long inspired artists, writers, and steamboat passengers. Visit Hannibal, the hometown of Mark Twain where the characters in his most popular works come to life. Immerse yourself in the culture of Memphis, the mid-South's most vibrant city, famous for Blues and BBQ.

As you journey down the river, hear stories about southern life on the plantation and tour historic Civil War sites led by our local area experts. On your final stop, New Orleans, enjoy privileged access to its vibrant music scene and the best in Cajun and Creole cuisine.  

Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.   



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River Cruise Itinerary

Day 1 New Orleans, LA

Welcome back to New Orleans, the birthplace of Jazz. Culture and art abound around every corner of this unique city. The open-air artist colony proudly displays local works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve its rich history. Stay an extra day or more to enjoy the famed French Quarter.

Day 2 Baton Rouge, LA

Experience the wonder of Baton Rouge, Louisiana's capital and one of the most historic and unforgettable cities in the South. Known as the Red Stick, Baton Rouge has everything you would expect to find in a state capital, but with a down-home flavor that is part of its charm.

Day 3 Natchez, MS

Settled in 1716, Natchez is rich in history and southern hospitality. Enjoy a guided exploration of this fascinating city which has retained its antebellum charm since its surrender during the Civil War. Visit Frogmore, a historic cotton plantation still in use today, or attend a special piano concert in the J. N. Stone music room.

Day 4 Vicksburg, MS

U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil War battlefields, century old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and learn about Vicksburg’s rich history as displayed on the riverfront murals.

Day 5 Day of Cruising

As you cruise toward the historic city of Vicksburg, enjoy the beauty of the heart and soul of the Mississippi Delta. Mingle with guests in one of our comfortable, read a good book on your private balcony, or take part in one of our many onboard activities.

Day 6 Memphis, TN

Excitement resonates as you reach America’s third-largest inland port, famous for Blues, BBQ, and Elvis Presley's Graceland. The city has been at the forefront of several American cultural movements such as Civil Rights and Rock ‘n’ Roll. In fact, the city’s Beale Street is often called “America’s Most Iconic Street” due to its significance to our country’s history and contributions to the music industry.

Day 7 Day of River Cruising

As you make your way from St. Louis to Memphis, reflect upon the rich history of the Mississippi River and the variety of music born upon its shores. Listen to the talented performers in one of our lounges or share the afternoon with fellow travelers.

Day 8 St. Louis, MO

Spend another day in this vibrant city, home to the Gateway Arch, Busch Stadium, and a variety of eclectic neighborhoods with great dining, micro-breweries, and live music. Led by our engaging guides, explore all St. Louis has to offer.

Day 9 St. Louis, MO

St. Louis is often referred to as the “Gateway to the West.” Take in the Gateway Arch Riverfront, highlighted by the Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.

Day 10 Hannibal, MO

Hannibal, “America’s Hometown,” is a place where you can rediscover adventures from Mark Twain’s era. Tom Sawyer and Huck Finn come to life in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans, filled with specialty shops unique to Hannibal.

Day 11 Fort Madison, IA

Foundedas an active military outpost in 1808, Fort Madison was one of three posts established by the U.S. Army to maintain control over the newly acquired Louisiana Territory. Today, Fort Madison offers visitors a vibrant cultural scene, bucolic landscapes, and an active agri-tourism industry which celebrates the American heartland. Explore its many historic districts, where you can admire the well-preserved Victorian and Post Renaissance architecture. Enjoy the area’s museums, unique boutiques, antique shops, as well as the local breweries and wineries.

Day 12 Davenport, IA

Voted one of the Most Livable Small Cities in America, Davenport is often described as a lively, active city with a hometown feel. The Legacy of John Deere, the largest agricultural exhibit in the world, resides here. Music enthusiasts will enjoy Davenport’s many festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival.

Day 13 Dubuque, IA

A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the river. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway, or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through the bustling downtown area, or visit the national Mississippi River Museum and Aquarium.

Day 14 Winona, MN

Step into 19th-century America in Winona, Minnesota, located in the picturesque bluff country on the Mississippi River. Explore this vibrant small town with the perfect blend of urban edge and old world charm. From rolling fields of prairie flowers to some of the most architecturally important buildings in Minnesota, enjoy all there is to see and do here.

Day 15 St. Paul, MN

St. Paul is a thrilling place to begin your adventure on the Mississippi River. History buffs will enjoy a walking tour of Summit Avenue, which showcases gorgeous historic mansions built in the late 1800’s. St. Paul’s enchanting art galleries, world class museums, and entertaining stage performances will capture your imagination.
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