15 Day American Cruise Lines River Cruise from St. Louis to Pittsburgh 2025

Day 1 St. Louis, MO

Prepare to be captivated by the irresistible charm of St. Louis. Take in the sweeping riverfront vista, dominated by the iconic Gateway Arch, a towering testament to human ingenuity and ambition, proudly standing as the largest man-made monument in the U.S.

Engage yourself in the city's wealth of world-class attractions, each offering a unique glimpse into St. Louis' rich history and culture. Explore the fascinating stories of the mighty Mississippi River at the National Great Rivers Museum, where tales of the river's past, its people, and its diverse ecosystems are recounted.

Discover the annals of time at the Missouri History Museum, situated within the expansive expanse of Forest Park, a site with a legacy tied to the legendary 1904 World's Fair. Stand in awe beneath the resplendent mosaic tile interior of the Cathedral Basilica, a testament to the city's enduring faith and architectural prowess.

Celebrate the spirit of American resilience and innovation at the newly renovated Gateway Arch monument, a beacon of the nation's western expansion, and its groundbreaking underground museum, offering a journey through history like no other. In St. Louis, every corner reveals an array of experiences, beckoning you to explore, uncover, and be inspired.

Day 2 Cruising the Mississippi River

On a journey to the Ohio River, we first have to cruise the Mighty Mississippi. Engage in onboard activities like trivia sessions in the lounge or a friendly game of shuffleboard on the top deck. You can always unwind on your private balcony and savor the idyllic countryside and panoramic river vistas as they roll by. Whether you seek excitement or tranquility, there's something for everyone on cruising days.

Day 3 Paducah, KY

Just upstream from your ship's mooring, the Tennessee River flows into the mighty Ohio River, painting a stunning portrait. Nearby, the confluence with the Cumberland River and the iconic Mississippi adds to the riverine symphony, creating a dynamic crossroads at the heart of Paducah's maritime legacy.

As you stroll along the bustling riverfront landing, you'll encounter a visual feast: over 50 intricate murals that vividly depict Paducah's dynamic history. These murals chronicle the town's pivotal moments, from its strategic significance during the Civil War to its emergence as a bustling river port that shaped the destiny of a nation.

For an artistic delight, visit the National Quilt Museum, located a mere block from the riverfront. Here, you'll be awestruck by an extraordinary collection of quilts, each an amazement in its own right and a testament to the skill of its artisans.

Day 4 Day of Cruising

Today, be on the lookout for the diverse array of wildlife that thrives in this region's rich ecosystem. Spot white-tailed deer gracefully bounding through the meadows, while cunning red foxes dart among the trees. Don't forget to watch for the adorable cotton-tail rabbits that scamper across the riverbanks, adding a touch of charm to your scenic journey. With every passing moment, the Ohio River reveals its vibrant and captivating tapestry of life, ensuring an unforgettable cruise experience filled with energy and excitement.

Day 5 Henderson, KY/Evansville, IN

Henderson, a relaxed river town, is imbued with stories and a deep sense of community. This town also served as the creative sanctuary for naturalist and artist John James Audubon in the early 1800s, where he crafted many of his stunning "Birds of America" masterpieces.

Just down the river, discover Evansville, a city that harmoniously blends contemporary and historical architecture. As the site of Bally's Evansville, Indiana's inaugural casino, the city offers a unique vibrancy alongside tranquil cultural sites like Mesker Park Zoo and Botanic Garden, one of the state's oldest and largest zoos. Experience the local culture with visits to the city's diverse museums and enjoy leisurely shopping and strolls through the enchanting streets of this scenic waterfront town. Each corner of Evansville offers a delightful mix of past and present, inviting visitors to explore and enjoy its unique charm.

Day 6 Day of Cruising

As you cruise along the grand Ohio River, experience the serene beauty of America's heartland. Witness the gentle sweep of greenery along the banks, interspersed with quaint towns that can be seen from the top deck. Partake in a variety of onboard activities designed to enrich your journey, from historical presentations to lively discussions, each adding depth to the stunning vistas that unfold before you. Let the rhythm of the river carry you through landscapes steeped in history, offering a peaceful yet engaging backdrop to your exploration. Each mile traveled is a new chapter in the unfolding story of the Ohio River, inviting you to witness its quiet waves and enduring charm.

Day 7 Louisville, KY

Louisville, a vibrant waterfront town, climbs gracefully up the hillside, its spirit etched deep into the fabric of American history. This city first flourished as a crucial portage around the perilous Falls of the Ohio, now tamed behind the expansive sweep of the Ohio River’s Markland Dam.

Step into the world of horseracing at the legendary Churchill Downs, home to the Kentucky Derby—the oldest continuously held horse race in the nation. For a slice of Americana, visit the Louisville Slugger Museum & Factory, where the iconic baseball bats are crafted.

No visit to Louisville would be complete without experiencing its famed bourbon heritage. Tour a local distillery, where the rich aroma of aging spirits fills the air. Sip the refined flavors of Kentucky bourbons, each taste telling a story of craftsmanship and the history of Bluegrass country.

Day 8 Day of Cruising

Settle in with your favorite book in one of the spacious lounges on our modern riverboat. Alternatively, relax on the sun deck or your private balcony, absorbing the views as we glide along the Ohio River from Cincinnati to Louisville. Witness the soft colors of the early morning fog lifting off the river, the gentle hills rolling in the distance, and quaint riverside towns passing by. This peaceful journey provides a calming backdrop for reflection and enjoyment as you watch the river landscape slowly transform with each bend.

Day 9 Cincinnati, OH

The striking bridges spanning the Ohio River create a magnificent entrance to Cincinnati, affectionately known as the “Queen City.” Originally a key shipbuilding and shipping metropolis, it has transformed into a dynamic cultural hub. Here, you can explore top-notch sports teams, the delightful Cincinnati Zoo and Botanical Garden, numerous theaters, and a range of museums, including the renowned National Underground Railroad Freedom Center, a Smithsonian Affiliate Museum.

Take a leisurely walk through the city streets, taking in the diverse architectural styles. Notable spots include the expansive Krohn Conservatory and the majestic St. Mary’s Cathedral Basilica. For a dish just as unique as the city itself try Cincinnati Skyline Chili or enjoy a scoop of ice cream from Graeter’s, a cherished establishment since 1868.

Day 10 Day of Cruising

Today is all about carefree enjoyment. Make the day your own and engage in fascinating presentations and fun-filled onboard activities. Enjoy gourmet meals and signature cocktails, and don’t miss freshly baked cookies at 3pm. Relax in our expansive lounges or feel the soft breeze on the sun deck, a prime spot for getting lost in a good book or engaging in conversations with new friends. It’s your day to simply relax and have a great time.

Day 11 Maysville, KY

From your vantage point on the ship's deck, take a moment to appreciate the scenic charm of Maysville, tucked into the hillside. This town marks a historic location, where early flatboat merchants, after trading down the Mississippi to New Orleans, journeyed back via the Natchez Trace Pathway to reconnect with the Ohio River.

Explore the town's pivotal role in the Underground Railroad, where daring escapes across the river were orchestrated. Uncover the story of Harriet Beecher Stowe’s visit, which profoundly influenced her writing of the classic story Uncle Tom’s Cabin. You'll also enjoy tales of notable locals such as the bold explorer Simon Kenton and the beloved singer and actress Rosemary Clooney.

Day 12 Day of Cruising

After a full day in Maysville, use this day on the river to recharge for more exploration ahead. Our crew has planned a variety of onboard activities for you to participate in. With onboard experts providing lectures and a wide-open sun deck, use today to do whatever it is you want.

Don’t miss cocktail hour to catch up with fellow travelers and get ready for a night of lively entertainment. Enjoy the ever-changing landscapes that unfold from the deck—scenes reminiscent of those witnessed by the earliest navigators of these waters. Each twist and turn of the river bring a fresh, breathtaking scene, offering a silent narrative of nature and history intertwined along these significant waterways.

Day 13 Marietta, OH

This quaint town sits at the meeting place of the Muskingum River and the Ohio River, home to five National Register Historic Districts featuring buildings that have stood since its founding in 1788. Stroll through the earliest settlement in the Northwest Territory, on the north side of the Ohio River. Listen to the stirring stories of significant events that unfolded here, as detailed in The Pioneers, the recent book by Pulitzer Prize-winning historian David McCullough.

Day 14 Moundsville, WV

Perched on the banks of the Ohio River, Moundsville, West Virginia, is a town woven with deep historical threads. Its name hails from the extensive Adena Indian burial mounds constructed over 2,000 years ago. Among these, it boasts the largest conical burial mound in North America—a testament to its ancient and monumental past. Today, Moundsville offers a dynamic blend of history and progress, characterized by its welcoming neighborhoods and scenic surroundings that capture the town's unique charm and potential.

Day 15 Pittsburgh, PA

Pittsburgh, once the beating heart of manufacturing, played a pivotal role in shaping the corridors of national and international commerce along the Ohio River. This industrious city flourished in the 18th and 19th centuries, its wealth evident in the grand architecture and the spirit of innovation that still permeates its streets. Upon your arrival, settle into your hotel, then step out to wander the city at your own pace.

Discover the legacies of American titans like Heinz and Carnegie, who planted their roots in this dynamic city. As you meander through the city, you'll feel the echoes of a rich past intermingling with the vibrant, forward-looking energy that defines Pittsburgh today.

Day 16 Pittsburgh, PA

Conclude your grand Ohio River voyage in this distinctive city, boasting frontier-town roots and the unassuming charm of the Midwest. As you journey home, take a moment to reminisce about the myriad of remarkable experiences you've encountered, or seize the opportunity to stay a little longer in this industrious city.