8 Day American Cruise Lines River Cruise from Louisville to Pittsburgh 2025

Day 1 Louisville, KY

An impressive waterfront town arching up the hillside, Louisville has a long history of commerce and revelry. The town grew at a portage around the treacherous Falls of the Ohio, now inundated behind the Ohio River’s Markland Dam. The historic importance of river commerce to the town is represented by the “Belle of Louisville” day excursion boat just down the banks, still operating after more than a century. Settle into your hotel and explore the city at your leisure.

Day 2 Day of Cruising

Board your ship and be treated to a Welcome Reception. Get to know your fellow guests and savor the view as you enjoy the afternoon cruising along the serene Ohio River.

Day 3 Cincinnati, OH

The dramatic bridges that span the Ohio River provide an impressive scenic welcome to your visit to Cincinnati. As an early shipbuilding and shipping metropolis, the town became known as the “Queen City.” Your adventures ashore reveal the highlights of this vibrant cultural center which include major sports franchises, a delightful zoo, and a botanical garden, as well as numerous theaters and museums, including the National Underground Railroad Freedom Center, a Smithsonian Affiliate Museum.

Admire the eclectic architecture as you stroll along its charming streets and enjoy the diverse attractions, ranging from the abundant gardens of the Krohn Conservatory to the architectural wonders of St. Mary’s Cathedral Basilica. Get a taste for local cuisine by trying Cincinnati Skyline Chili or stopping for a scoop at Graeter’s ice cream shop, founded in 1868.

Day 4 Maysville, KY

From the ship’s landing, gaze upon the quaint town of Maysville, nestled into the hillside. After floating down the Mississippi River to sell their commodities in New Orleans, early flatboat travelers returned along the Natchez Trace Pathway to rejoin the Ohio River in this idyllic town, steeped in American history.

Learn the importance of this location to the Underground Railroad efforts to smuggle runaway slaves across the river, as well as the influence that Harriet Beecher Stowe’s visit to Maysville had on her novel, Uncle Tom’s Cabin.Hear stories of area explorers, such as Simon Kenton, and hometown singer and movie star Rosemary Clooney.

Day 5 Day of Cruising

As you cruise along the grand Ohio River, experience the serene beauty of America's heartland. Witness the gentle sweep of greenery along the banks, interspersed with quaint towns that can be seen from the top deck. Partake in a variety of onboard activities designed to enrich your journey, from historical presentations to lively discussions, each adding depth to the stunning vistas that unfold before you. Let the rhythm of the river carry you through landscapes steeped in history, offering a peaceful yet engaging backdrop to your exploration. Each mile traveled is a new chapter in the unfolding story of the Ohio River, inviting you to witness its quiet waves and enduring charm.

Day 6 Marietta, OH

This picturesque, charming town rests at the confluence of the Muskingum River and the Ohio River and has five National Register Historic Districts with buildings that date back to the town’s founding in 1788. Explore the first settlement in the Northwest Territory on the north side of the Ohio River. Hear stories of the compelling events that unfolded here which were spotlighted in the recent book entitled, The Pioneersby Pulitzer Prize-winning historian David McCullough.

Day 7 Moundsville, WV

Located along the banks of the Ohio River Moundsville, West Virginia offers a rich history. Deriving its name from the many Adena Indian burial mounds constructed here more than 2,000 years ago, the town is home to the largest conical burial mound in North America. Moundsville is a land of sacred pasts and promising futures, accented with quaint neighborhoods, and beautiful landscapes.

Day 8 Pittsburgh, PA

Our ship docks near the famous point where the Allegheny and Monongahela Rivers join to begin the majestic Ohio River. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce making it a wealthy town in the 18th and 19th centuries. Hear tales of famous Americans such as Heinz, Carnegie, and others who called this vibrant city home.

As you cruise, delight in picturesque and ever-changing scenery, as early explorers did centuries ago. The surrounding hillsides provide a handsome backdrop for this fascinating city which was the gateway to the West for the young United States.

Day 9 Pittsburgh, PA

Enjoy breakfast on board the ship, before beginning your journey home. Reflect upon your adventures and the new friends made along the way.