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8 Day American Cruise Lines River Cruise from Memphis to New Orleans 2025
Lower Mississippi River Cruise
Starting from $4,210River Cruise Description
Embark on a unique riverboat adventure along the Lower Mississippi River between New Orleans, Louisiana and Memphis, Tennessee. Savor a week aboard our intimate and relaxed modern riverboat with 180 guests or fewer. Our enthusiastic all-American crew is ready to share with you a wonderful journey filled with historical tales, culinary delights, vibrant music, and new friends.
Dynamic presentations by your onboard speaker connect you to the region’s culture and history, while local guides share insights to illuminate your shore excursions. New Orleans reverberates with the sounds of jazz, while Memphis offers savory barbecue, rich music history museums, and an amazing exploration of Elvis’ Graceland. Discover why the Mississippi River and the port of Vicksburg were so important during the Civil War and enjoy the beautiful architecture, antiques, and gardens of grand estates alongside the river, including Houmas House, and Rosedown. Perhaps sip and savor a tasty mint julep while strolling under the canopy of 300-year-old trees at Oak Alley or peruse the local shops and museums of quaint and cozy towns like St. Francisville and Natchez.
Back aboard your riverboat, relax with our daily cocktail hour, hors d'oeuvres, a delicious meal, and an evening show as regional entertainers share the area’s renowned cultural flair.
Traveling with American Cruise Lines has never been easier. Ask about our brand new flat-rate domestic Airfare option available on our Lower Mississippi River Cruise itinerary.Thanks for your interest!
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I'm sorry, but an error has occurred. Try AgainDeparture Date | Ship | Priced From (per person) | |
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Feb 28, 2025 | American Serenade | $4,885 | Call Us! |
Mar 4, 2025 | American Splendor | $4,610 | Call Us! |
Mar 14, 2025 | American Serenade | $5,135 | Call Us! |
Mar 18, 2025 | American Splendor | $4,210 | Call Us! |
Mar 19, 2025 | American Symphony | $5,035 | Call Us! |
Mar 28, 2025 | American Serenade | $5,135 | Call Us! |
Apr 1, 2025 | American Splendor | $4,525 | Call Us! |
Apr 4, 2025 | American Melody | $5,245 | Call Us! |
Apr 5, 2025 | American Symphony | $5,245 | Call Us! |
Apr 11, 2025 | American Serenade | $5,495 | Call Us! |
Apr 15, 2025 | American Splendor | $4,925 | Call Us! |
Apr 18, 2025 | American Melody | $5,495 | Call Us! |
Apr 25, 2025 | American Serenade | $5,595 | Call Us! |
Apr 29, 2025 | American Splendor | $4,925 | Call Us! |
May 2, 2025 | American Melody | $5,595 | Call Us! |
May 9, 2025 | American Serenade | $5,995 | Call Us! |
May 13, 2025 | American Splendor | $4,925 | Call Us! |
May 16, 2025 | American Melody | $5,995 | Call Us! |
May 23, 2025 | American Serenade | $5,995 | Call Us! |
May 27, 2025 | American Splendor | $4,925 | Call Us! |
Jun 6, 2025 | American Serenade | $5,635 | Call Us! |
Jun 10, 2025 | American Heritage | $4,610 | Call Us! |
Jun 24, 2025 | American Heritage | $4,610 | Call Us! |
Jul 8, 2025 | American Splendor | $4,295 | Call Us! |
Aug 19, 2025 | American Splendor | $4,295 | Call Us! |
Sep 30, 2025 | American Splendor | $4,925 | Call Us! |
Oct 1, 2025 | American Splendor | $4,925 | Call Us! |
Oct 3, 2025 | American Heritage | $4,925 | Call Us! |
Oct 14, 2025 | American Splendor | $4,925 | Call Us! |
Oct 15, 2025 | American Splendor | $4,925 | Call Us! |
Oct 23, 2025 | American Serenade | $5,995 | Call Us! |
Oct 28, 2025 | American Splendor | $4,925 | Call Us! |
Nov 4, 2025 | American Symphony | $5,275 | Call Us! |
Nov 7, 2025 | American Melody | $5,275 | Call Us! |
Nov 9, 2025 | American Serenade | $5,275 | Call Us! |
Nov 11, 2025 | American Splendor | $4,295 | Call Us! |
Nov 18, 2025 | American Symphony | $5,275 | Call Us! |
Nov 21, 2025 | American Melody | $5,275 | Call Us! |
Dec 2, 2025 | American Symphony | $5,275 | Call Us! |
Dec 7, 2025 | American Symphony | $5,275 | Call Us! |
Dec 16, 2025 | American Symphony | $5,275 | Call Us! |
Dec 21, 2025 | American Symphony | $5,275 | Call Us! |
Dec 30, 2025 | American Melody | $5,275 | Call Us! |
River Cruise Itinerary
Day 1 Memphis, TN
Get ready to feel the vibrant soul of Memphis. This historic gem boasts a skyline that dances along the river, lined by swaying oak trees and historic landmarks. Feel the rhythm of the city through legendary Beale Street, alive with the sounds of blues and jazz. Indulge in mouthwatering BBQ, then unwind at The Guest House, your haven in this dynamic city.Day 2 Cruising the Lower Mississippi River
Step aboard your ship and set sail into a captivating experience. Begin with a warm welcome at the reception, an ideal place to connect with fellow travelers. As the ship elegantly cruises along the river, engage in the dynamic array of onboard entertainment. Each moment is designed to enhance your experience, promising a journey filled with delightful encounters and memorable entertainment.Day 3 Vicksburg, MS
Vicksburg resonates with historical significance, particularly during the Civil War, where its control marked a pivotal moment. Dubbed "The Gibraltar of the West," its fortified link between river and rail was crucial. Explore the National Military Park battlefield with a narrated tour, bringing its significance to life.
President Abraham Lincoln emphasized Vicksburg's importance, declaring it the key to closing the war. This port offers excursions abound, from museum visits guided by experts to solo explorations. Step onto an immense Army Corps of Engineers towboat or amble along the floodwall adorned with captivating murals, each panel narrating Vicksburg's tales with fervor. Engage with the energy of this historic gem, where every corner brims with stories waiting to be uncovered.Day 4 Day of River Cruising
Today is your day to unwind and take it all in. Glide effortlessly along the Mighty Mississippi, surrounded by breathtaking panoramas of cottonwood trees and graceful blue herons.
Engage in captivating enrichment sessions and lively onboard events. Delight in gourmet cuisine and refreshing cocktails. Whether you're lounging in our spacious lounges or basking in the sun on the deck, there's endless fun to be had. As Mark Twain famously said, it's a day with "nothing to hang a worry or a fret upon" – so let go and embrace the adventure!Day 5 Natchez, MS
Natchez, nestled along the Lower Mississippi River, is a treasure trove of history and architectural wonders. Founded in 1716, it bears the imprint of its French origins, evident in landmarks like Fort Rosalie, a testament to its colonial past. The town flourished during the antebellum era, with affluent planters erecting grand mansions such as Stanton Hall and Longwood, showcasing their wealth and influence.
Natchez preserves its heritage with hundreds of well-preserved enchanting homes, each telling a unique story. Take a stroll down historic Main Street, lined with charming shops and restaurants housed in restored buildings.
Explore the iconic Natchez Trace Parkway, tracing the footsteps of Native Americans and early settlers. Delve into the rich cultural heritage at the Natchez Museum of African American History and Culture, and the Historic Jefferson College. Natchez invites you to step back in time and immerse yourself in its fascinating history and Southern charm.Day 6 St. Francisville, LA
St. Francisville, Louisiana, invites you on a journey through time, blending history with mystery and culinary delights. Led by an expert historian, embark on a once-in-a-lifetime exploration of pivotal Battle of Baton Rouge locations and the significance of Vicksburg in the Civil War. Visit Fort Desperate, witness interpretive demonstrations, and hold artifacts from the battles.
Step into the haunting beauty of the Myrtles estate, built in 1796, renowned as one of America's most haunted homes. Marvel at its architectural splendor, adorned with exquisite details and surrounded by ancient live oak trees.
Experience the art of Cochon de Lait cooking, a cherished Louisiana tradition, while learning about its cultural significance. Indulge in a sumptuous spread of pork, Louisiana boudin, and traditional sides, accompanied by captivating stories of Louisiana's rich culinary heritage.Day 7 Baton Rouge, LA
Known for Cajun and Creole cuisine, this jazzy city is a melting pot of culture. Founded in 1699 by French explorers, its rich past is evident in its diverse architecture, from historic homes to modern skyscrapers.
The Louisiana State Capitol stands as an architectural marvel, boasting the title of the tallest capitol building in the United States. Its distinctive Art Deco style and towering presence make it an iconic landmark of Louisiana's political and historical significance.
Listen to the influence of all the people that make this city the landmark it is today. From soulful tunes to foot-tapping beats, the city's diverse musical heritage ensures an unforgettable experience for music enthusiasts.Day 8 Oak Alley, LA / Houmas House, LA
This iconic Southern estate is renowned for its oak-lined avenue, stretching majestically towards the Mississippi River. Built in the early 19th century, this Greek Revival mansion exudes charm with its grand architecture and lush gardens. Visitors are transported back in time as they explore the meticulously preserved interiors and learn about the land’s history, including its role in the sugar industry.
Houmas House and Gardens offers a glimpse into the opulent lifestyle of Louisiana's plantation owners. Known as the "Crown Jewel of Louisiana's River Road," this magnificent estate features stunning architecture, lush gardens, and luxurious interiors. Visitors can tour the lavishly decorated rooms, stroll through the expansive grounds, and enjoy fine dining at the onsite restaurant. Houmas House invites guests to step into a world of Southern splendor and hospitality.Day 9 New Orleans, LA
Established in 1718, this jazz-centric city features notable locations such as the French Quarter, with its ornate architecture, and Bourbon Street, famous for its bustling nightlife. Explore the historic St. Louis Cathedral, built in 1794, and Jackson Square, a hub of artistic and cultural activity.
Uncover the city's past at the National WWII Museum, honoring American soldiers' sacrifices during World War II. Wander through the Garden District, known for its elegant mansions and lush gardens.
Indulge in the city's culinary delights, including gumbo, po'boys, and beignets. Enjoy live music at venues like Preservation Hall and Tipitina's, or any sidewalk where jazz, blues, and funk fill the air.Having trouble deciding which cruise is right for you?