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8 Day American Cruise Lines River Cruise from New Orleans to Memphis 2025
Lower Mississippi River Cruise
River Cruise Description
Embark on a unique riverboat adventure along the Lower Mississippi River between New Orleans, Louisiana and Memphis, Tennessee. Savor a week aboard our intimate and relaxed modern riverboat with 180 guests or fewer. Our enthusiastic all-American crew is ready to share with you a wonderful journey filled with historical tales, culinary delights, vibrant music, and new friends.
Dynamic presentations by your onboard speaker connect you to the region’s culture and history, while local guides share insights to illuminate your shore excursions. New Orleans reverberates with the sounds of jazz, while Memphis offers savory barbecue, rich music history museums, and an amazing exploration of Elvis’ Graceland. Discover why the Mississippi River and the port of Vicksburg were so important during the Civil War and enjoy the beautiful architecture, antiques, and gardens of grand estates alongside the river, including Houmas House, and Rosedown. Perhaps sip and savor a tasty mint julep while strolling under the canopy of 300-year-old trees at Oak Alley or peruse the local shops and museums of quaint and cozy towns like St. Francisville and Natchez.
Back aboard your riverboat, relax with our daily cocktail hour, hors d'oeuvres, a delicious meal, and an evening show as regional entertainers share the area’s renowned cultural flair.
Traveling with American Cruise Lines has never been easier. Ask about our brand new flat-rate domestic Airfare option available on our Lower Mississippi River Cruise itinerary.Thanks for your interest!
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I'm sorry, but an error has occurred. Try AgainDeparture Date | Ship | Priced From (per person) | |
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Feb 21, 2025 | American Serenade | $4,775 | Call Us! |
Feb 25, 2025 | American Splendor | $3,895 | Call Us! |
Mar 7, 2025 | American Serenade | $5,135 | Call Us! |
Mar 11, 2025 | American Splendor | $4,210 | Call Us! |
Mar 12, 2025 | American Symphony | $5,035 | Call Us! |
Mar 21, 2025 | American Serenade | $5,135 | Call Us! |
Mar 25, 2025 | American Splendor | $4,210 | Call Us! |
Mar 28, 2025 | American Melody | $5,135 | Call Us! |
Apr 4, 2025 | American Serenade | $5,495 | Call Us! |
Apr 8, 2025 | American Splendor | $4,525 | Call Us! |
Apr 11, 2025 | American Melody | $5,495 | Call Us! |
Apr 18, 2025 | American Serenade | $5,495 | Call Us! |
Apr 22, 2025 | American Splendor | $4,925 | Call Us! |
Apr 25, 2025 | American Melody | $5,495 | Call Us! |
May 2, 2025 | American Serenade | $5,495 | Call Us! |
May 6, 2025 | American Splendor | $4,925 | Call Us! |
May 9, 2025 | American Melody | $5,495 | Call Us! |
May 16, 2025 | American Serenade | $5,495 | Call Us! |
May 20, 2025 | American Splendor | $4,925 | Call Us! |
May 30, 2025 | American Serenade | $5,495 | Call Us! |
Jun 3, 2025 | American Heritage | $4,610 | Call Us! |
Jun 3, 2025 | American Heritage | $4,610 | Call Us! |
Jun 17, 2025 | American Heritage | $4,610 | Call Us! |
Jul 15, 2025 | American Splendor | $4,295 | Call Us! |
Aug 26, 2025 | American Splendor | $4,295 | Call Us! |
Sep 26, 2025 | American Heritage | $4,925 | Call Us! |
Oct 7, 2025 | American Splendor | $4,925 | Call Us! |
Oct 8, 2025 | American Splendor | $4,925 | Call Us! |
Oct 16, 2025 | American Serenade | $5,995 | Call Us! |
Oct 21, 2025 | American Splendor | $4,925 | Call Us! |
Oct 22, 2025 | American Splendor | $4,925 | Call Us! |
Oct 31, 2025 | American Melody | $5,275 | Call Us! |
Nov 4, 2025 | American Splendor | $4,295 | Call Us! |
Nov 11, 2025 | American Symphony | $5,275 | Call Us! |
Nov 14, 2025 | American Melody | $5,275 | Call Us! |
Nov 25, 2025 | American Symphony | $5,275 | Call Us! |
Nov 29, 2025 | American Symphony | $5,275 | Call Us! |
Nov 30, 2025 | American Symphony | $5,275 | Call Us! |
Dec 9, 2025 | American Symphony | $5,275 | Call Us! |
Dec 13, 2025 | American Symphony | $5,275 | Call Us! |
Dec 14, 2025 | American Symphony | $5,275 | Call Us! |
Dec 22, 2025 | American Melody | $5,275 | Call Us! |
Dec 23, 2025 | American Melody | $5,275 | Call Us! |
Dec 24, 2025 | American Symphony | $5,275 | Call Us! |
River Cruise Itinerary
Day 1 New Orleans, LA
Settle into your hotel and enjoy a feast for your senses as you explore this magical city, renowned for its delicious cuisine, vibrant music scene, and rich culture with an international flair. Stroll the tree-lined avenues, take a carriage ride through the French Quarter, hop aboard a streetcar to the gorgeous Garden District, or visit the renowned National World War II Museum.Day 2 Cruising the Lower Mississippi River
Step aboard your ship and set sail into a captivating experience. Begin with a warm welcome at the reception, an ideal place to connect with fellow travelers. As the ship elegantly cruises along the river, engage in the dynamic array of onboard entertainment. Each moment is designed to enhance your experience, promising a journey filled with delightful encounters and memorable entertainment.Day 3 Oak Alley, LA / Houmas House, LA
This iconic Southern estate is renowned for its oak-lined avenue, stretching majestically towards the Mississippi River. Built in the early 19th century, this Greek Revival mansion exudes charm with its grand architecture and lush gardens. Visitors are transported back in time as they explore the meticulously preserved interiors and learn about the land’s history, including its role in the sugar industry.
Houmas House and Gardens offers a glimpse into the opulent lifestyle of Louisiana's plantation owners. Known as the "Crown Jewel of Louisiana's River Road," this magnificent estate features stunning architecture, lush gardens, and luxurious interiors. Visitors can tour the lavishly decorated rooms, stroll through the expansive grounds, and enjoy fine dining at the onsite restaurant. Houmas House invites guests to step into a world of Southern splendor and hospitality.Day 4 Baton Rouge, LA
Known for Cajun and Creole cuisine, this jazzy city is a melting pot of culture. Founded in 1699 by French explorers, its rich past is evident in its diverse architecture, from historic homes to modern skyscrapers.
The Louisiana State Capitol stands as an architectural marvel, boasting the title of the tallest capitol building in the United States. Its distinctive Art Deco style and towering presence make it an iconic landmark of Louisiana's political and historical significance.
Listen to the influence of all the people that make this city the landmark it is today. From soulful tunes to foot-tapping beats, the city's diverse musical heritage ensures an unforgettable experience for music enthusiasts.Day 5 Natchez, MS
Natchez, nestled along the Lower Mississippi River, is a treasure trove of history and architectural wonders. Founded in 1716, it bears the imprint of its French origins, evident in landmarks like Fort Rosalie, a testament to its colonial past. The town flourished during the antebellum era, with affluent planters erecting grand mansions such as Stanton Hall and Longwood, showcasing their wealth and influence.
Natchez preserves its heritage with hundreds of well-preserved enchanting homes, each telling a unique story. Take a stroll down historic Main Street, lined with charming shops and restaurants housed in restored buildings.
Explore the iconic Natchez Trace Parkway, tracing the footsteps of Native Americans and early settlers. Delve into the rich cultural heritage at the Natchez Museum of African American History and Culture, and the Historic Jefferson College. Natchez invites you to step back in time and immerse yourself in its fascinating history and Southern charm.Day 6 Vicksburg, MS
Vicksburg resonates with historical significance, particularly during the Civil War, where its control marked a pivotal moment. Dubbed "The Gibraltar of the West," its fortified link between river and rail was crucial. Explore the National Military Park battlefield with a narrated tour, bringing its significance to life.
President Abraham Lincoln emphasized Vicksburg's importance, declaring it the key to closing the war. This port offers excursions abound, from museum visits guided by experts to solo explorations. Step onto an immense Army Corps of Engineers towboat or amble along the floodwall adorned with captivating murals, each panel narrating Vicksburg's tales with fervor. Engage with the energy of this historic gem, where every corner brims with stories waiting to be uncovered.Day 7 Day of Cruising
Today is your day to unwind and take it all in. Glide effortlessly along the Mighty Mississippi, surrounded by breathtaking panoramas of cottonwood trees and graceful blue herons.
Engage in captivating enrichment sessions and lively onboard events. Delight in gourmet cuisine and refreshing cocktails. Whether you're lounging in our spacious lounges or basking in the sun on the deck, there's endless fun to be had. As Mark Twain famously said, it's a day with "nothing to hang a worry or a fret upon" – so let go and embrace the adventure!Day 8 Memphis, TN
Get ready to feel the vibrant soul of Memphis. This historic gem boasts a skyline that dances along the river, lined by swaying oak trees and historic landmarks. Feel the rhythm of the city through legendary Beale Street, alive with the sounds of blues and jazz. Indulge in mouthwatering BBQ, then unwind at The Guest House, your haven in this dynamic city.Day 9 Memphis, TN
Enjoy breakfast onboard the ship as you prepare for your journey home. Reflect upon the memorable experiences and the new friendships forged during your time with us.
Thank you for cruising with us. We hope your voyage was filled with delightful moments that you carry with you. Safe travels home, and we look forward to welcoming you aboard again soon.Having trouble deciding which cruise is right for you?