8 Day American Cruise Lines River Cruise from St. Paul to St. Louis 2022

American Cruise Lines River Cruise - St. Paul to St. Louis

Upper Mississippi River Cruise

Starting from $5,115
Ship(s): American Melody, American Symphony
American Cruise Lines
8 Day American Cruise Lines River Cruise from St. Paul to St. Louis 2022

River Cruise Description

The dramatic landscapes of the Upper Mississippi River have long inspired artists, writers, and steamboat passengers. It was here that literary great Mark Twain used the majestic river and its scenic bluffs as the settings in his most popular works. Visit his boyhood home in Hannibal, where the characters of Huck Finn, Tom Sawyer, and Becky Thatcher come to life.

Explore the beautiful gardens and historic homes of the region. Get close to nature in Red Wing as you witness a variety of bald eagle nests. Enjoy a guided tour of the Black Hawk State Historic Site which celebrates the story of the Sauk and Meskwaki Indians who once called Davenport home.

Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.   

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Departure DateShipPriced From
(per person)
Jul 15, 2022American Melody$5,115Call Us!
Jul 29, 2022American Melody$5,115Call Us!
Aug 12, 2022American Melody$5,115Call Us!
Aug 26, 2022American Melody$5,115Call Us!
Sep 9, 2022American Melody$5,115Call Us!
Sep 23, 2022American Melody$5,115Call Us!
Oct 1, 2022American Symphony$5,115Call Us!
Oct 7, 2022American Melody$5,115Call Us!
Oct 21, 2022American Melody$5,115Call Us!

River Cruise Itinerary

Day 1 St. Paul, MN

Your amazing cruise into the Heartland will disembark in Red Wing, MN. From there, we will transport to you to the St. Paul Airport. Or if you choose, stay an extra day or two in this vibrant river town.

Day 2 Red Wing, MN

Nestled among the scenic bluffs of the upper Mississippi River, Red Wing's beauty has inspired artists, writers, and musicians for over 150 years, delivering a diverse blend of arts, entertainment, and activities for your pleasure. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.

Day 3 Winona, MN

Step into 19th-century America in Winona, Minnesota, located in the picturesque bluff country on the Mississippi River. Explore this vibrant small town with the perfect blend of urban edge and old world charm. From rolling fields of prairie flowers to some of the most architecturally important buildings in Minnesota, enjoy all there is to see and do here.

Day 4 Dubuque, IA

A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the Mississippi River. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through the whimsical downtown area, and visit the national Mississippi River Museum and Aquarium.

Day 5 Davenport, IA

Voted one of the Most Livable Small Cities in America, Davenport is often described as a lively, active city with a hometown feel and features the largest agricultural exhibit in the world. Music enthusiasts will enjoy Davenport’s many music festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival which is dedicated to native Jazz musician Bix Beiderbecke.

Day 6 Fort Madison, IA

Founded as an active military outpost in 1808, Fort Madison was one of three posts established by the U.S. Army to maintain control over the newly acquired Louisiana Territory. Today, Fort Madison offers visitors a vibrant cultural scene, bucolic landscapes, and an active agri-tourism industry which celebrates the American heartland. Explore its many historic districts, where you can admire the well-preserved Victorian and Post Renaissance architecture. Enjoy the area’s museums, unique boutiques, antique shops, as well as the local breweries and wineries.

Day 7 Hannibal, MO

Explore Hannibal, “America’s Hometown,” and experience theboyhood adventures of Mark Twain. Tom Sawyer and Huck Finn come to life in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans filled with specialty shops unique to Hannibal.

Day 8 St. Louis, MO/Alton, IL

Alton is an idyllic town, known for its scenic limestone bluffs along the river and its rich Civil War history. The National Great Rivers Museum, located at the Melvin Price Lock and Dam, tells the stories of the Mississippi River’s history, the people that rely on the River, and its many ecosystems. Hometown of jazz musician Miles Davis and Robert Wadlow, the tallest known person in history (8’11”), Alton is an inspiring and picturesque destination and the perfect place to begin your Upper Mississippi journey.
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