22 Day American Cruise Lines River Cruise from New Orleans to St. Paul 2026

American Cruise Lines River Cruise - New Orleans to St. Paul

Complete Mississippi River Cruise

Starting from $15,640
Ship(s): American Melody, American Serenade
<span>22 Day American Cruise Lines River Cruise from New Orleans to St. Paul 2026</span>

River Cruise Description

Sail 1,393 miles, through 10 states, on the most comprehensive exploration of the Mighty Mississippi available. This epic cruise showcases the culture and cuisine of the historic South, and the rolling farmlands of the Midwest as we explore the entire length of this legendary river. We embrace the relaxed pace of life on the River, following its bends and savoring its charms in much the same way as travelers and colonists would have over a century before.

Our onboard experts bring the stories of the River to life and provide context to each shore experience we provide along the way. This epic 22-day exploration of America begins in New Orleans and travels north, visiting new ports of call each day before concluding in Minneapolis.



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May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$16,640Call Us!
May 23, 2026American Melody$16,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$16,640Call Us!
May 23, 2026American Melody$16,255Call Us!
May 23, 2026American Melody$16,255Call Us!
May 23, 2026American Melody$15,640Call Us!
May 23, 2026American Melody$16,640Call Us!
May 23, 2026American Melody$16,640Call Us!
May 23, 2026American Melody$16,640Call Us!
May 23, 2026American Melody$16,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$16,255Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!
Jun 13, 2026American Serenade$16,255Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$15,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!
Jun 13, 2026American Serenade$16,640Call Us!

River Cruise Itinerary

Day 1 New Orleans, LA

Welcome to New Orleans, a city celebrated for its nightlife and dynamic live-music scene, where jazz, blues, and zydeco melodies spill from every corner. French, African, and American influences come together to create some of the iconic dishes this city is famous for. As you settle into your hotel, take the opportunity to explore at your own pace. Wander the historic French Quarter, let the aromas of gumbo and beignets guide you, and notice the draping greenery from windowsills, intricate iron balconies, and the pastel-colored facades of the Creole townhouses that line the cobblestone streets.

Each Mississippi itinerary comes complete with aHotel Stay, providing you with a seamless way to board the ship and explore the local area.

On the morning of the cruise, meet in the hotel lobby and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.

Day 2 Day of River Cruising

Board your ship and wave goodbye to New Orleans with a welcoming reception, a perfect opportunity to meet fellow travelers as you begin the ultimate Mississippi River adventure. As the ship sets off, get ready to see the stunning panoramas that have sparked the imaginations of some of America's most legendary writers, artists, and musicians. Watch as river towns and changing environments unfold around you, each bend in the river promising new surprises and thrilling discoveries.

As you embark upon your journey, enjoy a Welcome Aboard Reception with cocktails, hors d’oeuvres and entertainment. Meet the crew, your onboard experts, and fellow guests. Learn more about the wonderful adventure ahead of you.

Day 3 Oak Alley, LA

Once a thriving sugar cane estate, Oak Alley is named for its most striking characteristic: a cathedral of towering oaks, their ancient limbs arching softly to form a verdant canopy that leads like a green-veiled aisle along the river. At its heart stands the mansion, a testament to Greek Revival elegance, its columns holding the sky, a beacon of time held in white marble. This grand edifice, restored to its nineteenth-century glory, stands as a solemn yet striking guardian of history, breathtaking in its stoic beauty.

From its canopy of 300-year-old oaks to its vast open spaces, Oak Alley's landscape tells the story of a southern plantation over time. Over 200 years ago, Oak Alley was just a land claim on a map and has since served many purposes, including as a sugar plantation, a rice farm, a chicken farm, a cattle ranch, and a country home. Agricultural tycoons, sugar planters, slaves, immigrant laborers, and real estate speculators have traversed its grounds over time.

Today, Oak Alley is a National Historic Landmark dedicated to preserving and interpreting the history of its inhabitants. With an emphasis on its time as a sugar plantation, visitors are invited to walk under its iconic alley, explore the exhibits, interact with staff, and leave with a richer, more powerful understanding of this plantation's complex history. For the full southern experience, don't forget to take time for a complimentary mint julep.

Activity Level: High | ADA Accessibility: Partial

Day 4 Houmas House, LA

Houmas House Estate stands as a beacon of southern elegance amid the Louisiana countryside, its historical roots intertwined with sugar cane cultivation. Encircled by ancient oaks and meticulously tended gardens, the mansion showcases classic architecture, featuring grand staircases and opulent rooms that hint at what life was like for the Southern elite. Often referred to as "The Sugar Palace," this estate displays a lavish array of blooms and greenery, creating an inviting atmosphere for visitors to explore its beauty.

Enjoy a narrated boat ride in the Manchac Swamp, a privately owned wildlife refuge. Relax in a comfortable, covered boat, with walking room and open viewing from any seat. Swamp creatures are unafraid and responsive to our captain’s voice. In the safety and comfort of the boat, you will be able to get within a few feet of our “jumping gators.” Other animals to be on the lookout for include nutria, ibis, turtles, herons, raccoons, egrets, and more.

Activity Level: Moderate | ADA ACCESSIBLE: No

Admire the southern splendor of “The Sugar Palace,” as you step into 16 rooms filled with rare period antiques and Louisiana artwork. Explore the mansion, which has been restored to the antebellum era, reflecting the opulence and wealth that this sugarcane farm boasted during the 1800s. Learn about plantation life and the 250-year history of the manor, including its architectural evolution to becoming a grand estate.

Activity Level: Moderate| ADA ACCESSIBLE: No

Come “veiller” (shoot the breeze) with Boudreaux and Thibodeaux as you stir up your very own “ti” (junior) pot of jambalaya in the old Robert Barn by the Cajun Cottages. Be entertained with Cajun folktales while getting step-by-step coaching from a local Cajun jambalaya cook. After dining, enjoy shopping in the Cajun Village, a unique location with specialty crafts and Louisiana items. In case you have the “envie” (craving) for a cup of café au lait and beignets, you can swing by the Coffee House for complimentary beignets. Activity Level: Moderate / ADA Accessible: Partial

Step beyond the myths of the American South to experience true-life, first-hand compelling accounts of four generations of Créole women, children, and slaves. Experienced guides transport you into the complex, vanishing world of Créole Louisiana at Laura Plantation, a 200+ year-old sugar habitation. A new, permanent exhibit honors the men, women, and children who were enslaved here, including detailed biographies of former slaves who fought for the freedom in the Union Army during the Civil War. Activity Level: Moderate / ADA Accessible: No

Day 5 Baton Rouge, LA

Originally named for a 'red stick' marker used by Native Americans, this city now serves as the historic capital of Louisiana. Baton Rouge reverberates with the stories of its most notable figures, particularly the bold Governor and Senator Huey P. Long. His political and architectural legacies are enshrined at the Old State Capitol Museum, housed in a majestic Gothic-style castle from 1852, and the towering 34-story State Capitol, a masterpiece of Depression-era art deco architecture made from Louisiana limestone and adorned with marble.

Take a walk through the heart of Baton Rouge's downtown, where contemporary art installations stand in contrast to classical revival and modernist facades. For an immersive natural encounter, step aboard a boat for a guided excursion through the dense, waterlogged ecosystems of the nearby swamps, home to alligators and cypress trees draped in Spanish moss.

Experience the sights, sounds, and wonders of Baton Rouge, the Capital City of Louisiana. Led by a local expert guide, admire iconic and historical landmarks while exploring many of the well-known downtown neighborhoods on foot. Enjoy fascinating stories of the area’s culture, politics, history, and legends while embracing the rich art, architecture, and nature on the route. Walk past the levee, USS KIDD, Louisiana Art and Science Museum, the Capitol Building, and through Spanish Town.

Activity Level: High| ADA ACCESSIBLE: No

Housed in a historic railroad depot on the banks of the Mississippi River, the Louisiana Art & Science Museum (LASM) offers educational entertainment for visitors of all ages. The art galleries showcase changing fine art exhibitions and selections from a permanent collection. The Ancient Egypt Gallery houses ancient artifacts and a Ptolemaic-era mummy that rests in a re-created rock-cut tomb. The Irene W. Pennington Planetarium features sky shows, large-format films, visual music shows, and galleries devoted to space science.

Activity Level: Low| ADA ACCESSIBLE: Yes

Being your excursion with a narrated city exploration with views of the impressive Governor's Hall and the New State Capitol. Admire the Old Louisiana State Capitol also known as the State House. Enjoy views of Magnolia Mound, a French Creole plantation house built in 1791 and a rare example of the architecture influenced by early settlers from France and the West Indies.

Next you will be driven to the LSU Rural Life Museum; a museum dedicated to the preservation and exhibition of materials from the cultures of 18th and 19th-century rural Louisianans. The museum highlights how the rest of the south lived in comparison to the mansions and plantations visited throughout this itinerary. Experience life in a rural setting in the early lives of Louisiana during the 18th and 19th centuries. You will leave the facility with a better understanding of the differences in the material, social, and economic cultures during this time period, and of today's lifestyles.

Activity Level: Moderate| ADA ACCESSIBLE: Partial

Experience the mighty Mississippi River from the unique perspective of your personal boat captain who has spent a lifetime on the river – a modern-day Mark Twain! Witness the bustling activity around Baton Rouge and hear countless stories and amazing facts about the Mississippi River’s round-the-clock towing industry. Marvel at the sheer size of the panamax vessels operating in this part of the river and pass the nearby the Exxon facility where you are likely to see the ships loading petroleum for shipment overseas. Learn how the river barges are lashed together with ratchet straps and thick cables and how the experienced river tug captains safely navigate the river with numerous barges in tow. See the Dreyfuss grain elevators working in tandem with the barges being loaded and unloaded, fueling the country’s Midwest commerce. Pause underneath the towering I 10 Bridge en route to Mulatto Bend and hear how the original community was washed away by the river, where the renowned Southern University now stands.

Activity Level: Moderate / ADA Accessible: Partial

Led by an expert historian, explore locations that were critical to the Battle of Baton Rouge and hear about the history surrounding Vicksburg in the Civil War. Visit the historic Magnolia Cemetery and stand upon the very ground where the most intense fighting of the battle took place. Baton Rouge was the most fought over land in Louisiana’s history and this experience will cover not only the Civil War, but the American Revolution and the Florida Rebellion. Although the landscape of Baton Rouge isn’t the same as it was in the 1780s or 1810s, its history will be brought to life by your guide. Visit the Magnolia Mound Plantation, a Baton Rouge city park. Magnolia Mound, unlike other antebellum house museums along the Lower Mississippi, is not your grand mansion. Rather, it’s a simple structure built during Louisiana’s colonial history, and around the time of its Statehood into the Union. Activity Level: Moderate / ADA Accessible: Yes

Day 6 St. Francisville, LA

St. Francisville, Louisiana offers a glimpse into the quaint charm of small-town America wrapped in Southern Gothic intrigue. This historic town is celebrated for its beautifully preserved historic homes like the Myrtles, reputed to be one of America's most haunted houses, and the graceful Rosedown, standing out amidst 28 acres of gardens.

Visit the enchanting Historic District, where opulent mansions and eclectic boutiques wait, and take in the captivating contrast of cottonwood trees giving way to regal oaks dripping in Spanish moss.

Led by an expert historian in a once in a lifetime opportunity, explore locations that were critical to the Battle of Baton Rouge and hear about the history surrounding Vicksburg in the Civil War. You will learn about the culminating battle and Campaign to open the Mississippi River. Visit Fort Desperate, the only location on the battlefield assaulted twice, see an interpretive demonstration, have the opportunity to hold bullets and artillery shells fired during the battles, and have a private guided exploration of the museum

Activity Level: Moderate | ADA ACCESSIBLE: Yes

Enjoy a hands-on experience in the gallery and at several outbuildings, including ahome exploration, a cooking demonstration with samples, a blacksmith demonstration, a short exploration of the grounds, and a museum visit.

Explore the unique home where Audubon resided. Audubon Historic Site is located on Oakley Plantation where John James Audubon lived and worked 1821, completing or beginning 32 of his bird paintings while in residence. During this time, he was commissioned to teach illustration to the daughter of Mr. and Mrs. James Pirrie, owners of Oakley. Although his engagement was brief and there is no record of his success in teaching Miss Pirrie, Audubon worked on several of his paintings while in the lush, natural, and peaceful setting of Oakley, filling his sketch pad with notes and drawings for his famous series of bird illustrations.

Activity Level: Moderate| ADA Accessibility: No

Explore and learn about the legacy and lineage of the Turnbull family at Rosedown and Catalpa. On the National Listing of Historic Landmarks, Rosedown is located in one of the most historic corridors of South Louisiana. The presence of the Mississippi River along its shores created rich soil overtime which proved extremely valuable during the cotton boom. As you stroll through this grand estate, local guides will regale you with stories of the families who lived there and plantation life in the 1800s. Enjoy exploring one of the few and largest privately maintained formal gardens of the 19th century.

Visit Catalpa and hear from Mary, a descendant of the original owners. She will host you in her gracious home filled with the treasures of five generations and recount stories of the family and growing up in this beautiful place. Fine portraits, exceptional antiques and beautiful old china, porcelain and silver are original to either Catalpa or Rosedown, home of the owner's grandmother. Conclude your exploration with a special beverage that has been served for years at Catalpa.

Activity Level: Moderate | ADA ACCESSIBLE: No

At first glimpse Myrtles, built in 1796, envelopes one with a complete sense of peace and tranquility. However, it is reputed to be one of the most haunted homes in America. Surrounded by centuries-old live oak trees, the mansion features a 125-foot verandah, exquisite ornamental ironwork, hand-painted stained glass, open-pierced frieze work crown molding, Aubusson tapestry, Baccarat crystal chandelier, Carrara marble mantels, gold-leafed French furnishings and ghosts.

Activity Level: Moderate | ADA Accessibility: Yes

Day 7 Natchez, MS

In the heart of Natchez, where the mighty river bends and twists, stand grand homes that gleam with the opulence of ages past. From the moment the French built a fort here in 1716, amidst the communities of the Natchez Indians, this town began to grow into a wealthy river town.

Behold, the legacy of the 1800s planters, who sculpted their dreams into reality with mansions. Unscathed by Civil War strife, Natchez stands as a unique sanctuary. In the labyrinthine streets, where time itself seems to slow, encounter the fabled Under-The-Hill Saloon, a relic of days long gone but never forgotten.

Explore the Historic Natchez Cemetery. Established in 1822, the occupants of this important cemetery tell tales of the history, grandeur, mystery, and tragedy of Natchez. Surrounded by majestic live oaks and set on the bluffs high above the Mississippi River, the beautiful grounds offer stunning panoramic views. Enjoy a guided walking excursion through the oldest section of the cemetery and hear fascinating stories about the residents buried there.

Activity Level: Moderate| ADA ACCESSIBLE: Partial

Nineteen historical buildings, dating from 1790’s to 1900, are a restored tribute to Frogmore Cotton Plantation & Gins, a modern 1,800-acre working cotton estate with a computerized farm and gin. Before beginning your exploration, meet the owner who will explain the farming and ginning operations. Participate in picking cotton and removing the seeds and tour a rare, steam engine gin listed on the National Register of Historic Properties.

Be seated in the hand-hewn log cabin and listen to narration and the vocalist’s songs highlighting the history of southern plantations, including the Constitution, Emancipation Proclamation, and accurate statistics of the enslaved and planter families. After an enlightening overview of the historical Frogmore owners, explore the cotton fields and authentic cabins to learn the origin of southern cuisine, the day-to-day operations and how their labor force evolved into sharecropping, a way of life for 100 years. Enjoy a complimentary beverage as you browse an original plantation store.

Activity Level: Moderate| ADA Accessibility: Partial

Experience a once-in-a-lifetime outdoor adventure at the Double C Ranch, perfect for nature-lovers and wildlife-enthusiasts. Aboard your private sport utility vehicle, guided by a local professional, enjoy breathtaking views as you travel through scenic hardwood forest, cattle fields, farmlands, and pine plantations. Back at the ranch, watch in awe during live tomahawk throwing, bullwhip popping, archery, and lasso throwing demonstrations. After, get some pointers on form and technique and prepare to shine and surprise yourself as you give it a try! Take home a survivor certificate and photos to share.

Activity Level: Moderate| ADA Accessibility: No

This is a Signature shore excursion and should be reserved in advance. Please call (800) 894-8570 for information.

Longwood, the only octagonal mansion in the region, epitomizes the rise and fall of the South. As the Civil War began, the workmen stopped construction and the house was never completed. View the finished lower level still adorned with original family furnishing and the upper stories and rotunda that are still a work in progress. This truly is a place where time has stood still, preserved for all to experience.

Activity Level: Moderate| ADA Accessibility: Partial

Take a cultural, moving journey through the history of Natchez that goes beyond grand estates and mansions and tells the stories of African Americans, from slavery and the Civil Rights Movement to the present day.

Along this Historic Path to Freedom, you will visit Dunleith Mansion to learn about John Roy Lynch, a child servant who became the first African American to become a member of the U.S. House of Representatives. Your exploration will continue through Natchez, where you will see and learn about places such as "Forks in the Road" and the RhythmNightclub Fire site.

Travel to the Zion Station Chapel African Methodist Episcopal Church for a brief introduction by the Pastor and a spiritual musical experience by Natchez noted gospel performers. Learn about The Parchman Ordeal and how it forged the way for economic progress for the African American citizens of Natchez. This well-told, enlightening experience will conclude with a visit to the Natchez Museum of African American Culture, where the exhibits will underscore the importance of the stops made along this exclusive American Cruise Lines experience.

Activity Level: Low| ADA Accessibility: Yes

Join a local guide for a unique and unforgettable experience, combining the history and culture of Natchez, with the opportunity to taste some of the most iconic cocktails of the region. On a guided exploration, admire the architecture and design of two historic mansions. Make a stop at Historic Dunleith, where you will be welcomed with the refreshing taste of hibiscus mimosas, a classic cocktail made with freshly squeezed orange juice, champagne, and a house-made hibiscus syrup. While sipping, learn about Natchez history and admire the beauty of this mansion built in 1856, as well as the stunning grounds. Continue on to Historic Linden, an early suburban villa, where you will have the chance to try a classic southern cocktail, milk punch. Dating back to the 18th century, this libation is made with brandy, milk, sugar, and nutmeg. Delight in the rich and smooth taste, while learning about the legends of Linden, built in 1790. Activity Level: Low |ADA: Partial

Board this convenient shuttle, making stops at:

Activity Level: Low| ADA ACCESSIBLE: Yes

Experience a multitude of National treasures, historic sites, and local points of interest from the comfort of your motorcoach. Natchez boasts more National Landmarks than any other town in Mississippi. Begin your exploration atthe mighty Natchez Bluffs overlooking the Mississippi River. Yourlocal guide will entertain you with local lore and legends, in addition to historical facts.Viewhistoric architectural gems, African American sites, local favorites, and a few quirky place. Complete your experience with a complimentary guided exploration of Historic Rosalie Mansion, so exquisite, she’s known as "Our Lady on The Bluff." Activity Level: Low| ADA Accessibility: No

Day 8 Vicksburg, MS

In the heart of Mississippi lies Vicksburg, a crucible of fate during the Civil War. Dubbed "The Gibraltar of the West," its strategic importance was clear to President Lincoln. The National Military Park tells the tale of valor and sacrifice that shaped nations. Along the floodwall, murals recount Vicksburg's legends, each stroke a brushstroke upon memory's canvas. Here, amidst the movement of the river, Vicksburg's spirit beckons as a beacon of remembrance. In the shadow of Vicksburg's towering history, visitors can feel the weight of the past, a testament to the enduring legacy of a nation forged in the fires of conflict.

A knowledgeable guide will lead you through the National Military Park which commemorates the campaign, siege, and defense of Vicksburg in 1863.Stop at the impressive Illinois Monument, modeled after the Roman Pantheon. The exploration concludes at the Visitors Center where life-sized exhibits and artifacts from the Siege of Vicksburg are on display.

Activity Level: Low| ADA ACCESSIBLE: Partial

Come along and feel what life was like in the 19th century on this excursion into Vicksburg’s oldest historic neighborhood. Visit Christ Episcopal Church (circa 1839) and view its beautiful Tiffany windows amidst its Gothic revival architecture. The Rector will recreate the stories and history of this church including how the surrounding cannonball fire rang out all around during the siege of Vicksburg.

The second stop is a short walk alongside the neighborhood’s brick streets to Duff Green Mansion (circa 1856). The owner, Harley Caldwell, invites you into her home as a guest of honor. Imagine that you are part of a dinner party hosted by Duff Green and his wife, Mary, back in the 1800’s as you listen to Harley discuss the history of the house and what was happening in Vicksburg at that time. This is the one mansion where the ropes are gone, and you can sit on the furniture and make yourself at home. Experience Vicksburg’s good old fashioned Southern hospitality out of Harley’s silver punchbowl. A short motor coach ride will take you to the last stop of this excursion, Tully’s Cave. The residents of Vicksburg moved into caves for 47 days as the city was bombarded with cannonball fire throughout all hours of the day. Walk through a cave and learn why most of the residents survived the attack.

Activity Level: Moderate| ADA ACCESSIBLE: Partial

Led by a guide, visit Oak Hall, a gorgeous 1910 Mission Revival style mansion that boasts 32 Louis Millet stained glass windows. Gather around the table to learn how to build an aesthetically pleasing presentation of a selection of a variety of Mississippi made or harvested meats, cheeses, spreads, seasonal fruits, nuts, and other accompaniments. Taste seasonal, local products and experience hospitality at its finest. Wow your guests at your next gathering by learning some advanced charcuterie techniques. Top off your experience with cocktails and mocktails made with local products and receive recipes and a souvenir mini board to take home. Activity Level: Low / ADA Accessible: No

Bringing to life the history of this river city from before 1820 to present day, you will explore early Vicksburg in one of the most historical areas of our city. As you leisurely walk the brick streets your guide will draw your attention to antebellum homes with varying architecture, museums with rich history, native flora, and history of past citizens. You will make a stop to enjoy a tasty root beer float at the Biedenharn Coca-Cola Museum, where Coca-Cola was first bottled and spend a little time in the Old Cout House Museum. The exploration wouldn't be complete without a final stop at Anchuca, an incredible 1830's antebellum mansion turned bread and breakfast. This is a great opportunity to take in some fresh air and exercise as well.

Activity Level: High| ADA ACCESSIBLE: No

Board this convenient shuttlemaking stops at:

Activity Level: Low | ADA Accessibility: Yes

Day 9 Greenville, MS

Dubbed the Heart and Soul of the Mississippi Delta, Greenville offers a glimpse into traditional southern living. Explore historic landmarks such as Cotton Row, Mount Holly Plantation, and the Weatherbee House. Experience the essence of the state’s largest city as you journey through its storied past. As the sun sets over Lake Ferguson, feel Greenville's timeless allure envelop you, inviting you to become part of its ever-unfolding story.

The B.B. King Museum and Delta Interpretive Center is located in the heart of the Mississippi Delta between Greenwood and Greenville. Opened in mid-September 2008 and built to honor the life and music of one of the most accomplished musicians of our time, the museum serves as a vital resource to the State of Mississippi and the City of Indianola. The museum’s exhibits and educational programs were designed to preserve the rich cultural and musical heritage of the Mississippi Delta.

Activity Level: Low| ADA Accessibility: Yes

Explore three museums in the city of Greenville at your leisure. The Greenville History museum is housed in the restored Miller Building and provides a glimpse into local history from the late 1800’s to the 1970’s. The 1927 Flood Museum commemorates one of the country’s worst natural disasters in history, the break in the levee, which is reported to have put flood waters over the rooftops of houses 75 miles away. At the Jewish Temple Museum, learn how this religion began to flourish within the region.

Activity Level: Low| ADA Accessibility: Yes

Day 10 Tunica, MS

In the embrace of the Delta , Tunica, reveals itself as a living testament to history and charm. Its Main Street, frozen in time, boasts buildings that have been engrained in the landscape since the turn of the century, each a stalwart witness to bygone days. Stroll through unique boutiques and antique shops, keeping the past alive. Be captivated by the fully restored courthouse, a symbol of justice, and pay homage at the Tunica Veterans Memorial in Rivergate Park, honoring the valor of generations. Tunica extends a warm welcome to you to experience southern hospitality, a timeless port town awaiting exploration.

Before you trek through blues country, get in a blues state-of-mind at the Gateway to the Blues Museum, set in a rustic train depot, circa 1895. Here, the story of the blues comes to life in all its tormented and anguished glory. Experience interactive exhibits, view amazing artwork, and more,including a recording studio where you’ll learn the basics of blues music with a chance to record your very own blues song.

Walk from the ship to the scenic Tunica RiverPark to enjoy the awe-inspiring beauty of the Mississippi River. The grounds are rich with native wildlife and flora, and the stunning architectural features of the RiverPark Overlook provide breathtaking views of the river. Take a walk on one of the nature trails, including a paved path along the Mississippi River (Promenade Trail), a dirt path/boardwalk (Boardwalk Trail) around a small lake, and a single track path through the forest (Wildlife Trail). Visit the onsite Mississippi River Museum, which features authentic artifacts and exhibits, showcasing the history, nature, and culture of the region.

Day 11 Memphis, TN

Welcome to Memphis, where history beats to its own drum. Wander through Beale Street, where the strums and songs of legendary musicians still linger. Taste the city’s renowned BBQ, a mouthwatering delight dripping in sweetness. Explore historic sites that commemorate the Civil War and Civil Rights Movement, and indulge in crispy fried catfish, a southern classic that can’t be missed.

Discover the birthplace of rock 'n' roll at Sun Studio, where Elvis Presley recorded his earliest hits, and feel the rhythm and blues that define the city's soul. Finally, unwind aboard your ship at Beale Street Landing, serenaded by local musicians under the stars as you reflect on the day's adventures. Welcome to Memphis – where every moment is a melody waiting to be heard.

For any fan of Elvis, this is the ultimate way to experience Graceland and to learn about his life and musical career. Visit Graceland Mansion and four new exhibits on the property, including the Elvis Presley Car Museum. Climb aboard one of his custom airplanes, remodeled to suit his lifestyle. Enjoy authentic Memphis cuisine at one of the themed restaurants on the property. Following Graceland, enjoy a brief city motorcoach exploration of Memphis. This excursion is perfect for any rock ‘n’ roll music lover.

This is a Signature shore excursion and should be reserved in advance. Please call (800) 894-8570 for information.

Activity Level: High| ADA Accessible: Partial

Established in 1991, the National Civil Rights Museum is located at the former Lorraine Motel, where Dr. Martin Luther King Jr. was assassinated in 1968. The museum’s mission is to share the history of the American Civil Rights Movement, a tumultuous and inspiring period of change. Explore interactive exhibits and historic collections to learn how this significant era continues to shape equality and freedom today.

Activity Level: Low| ADA ACCESSIBLE: Yes

Explore the captivating city of Memphis at your leisure with our convenient shuttle, making stops at:

Activity Level: Low| ADA Accessibility: Yes

Relax and let your motorcoach guide show you the highlights of this fascinating city on the bluff. Memphis is located on the Mississippi River at the northern end of the Mississippi Delta where the Blues were born. Its history is linked to cotton and music. Along your exploration, stop at the Lorraine Motel, the location where Dr. Martin Luther King, Jr. was assassinated.

The next photo opportunity will be at the famous Sun Studio, the birthplace of rock ‘n’ roll. You will also have the option to walk through the Peabody Hotel and see the famous ducks in the fountain. Enjoy some time at the Memphis Pyramid, housing an impressive Bass Pro Shop, a Lodge, Restaurants and more. During the excursion, you will be driven through the streets of downtown Memphis. You will see Victorian Village, Orpheum Theater, Rock N Soul Museum, St. Jude's Children's Hospital, Cotton Row, Beale Street, Lauderdale Courts, early home of Elvis Presley, Sun Studio,and the Auto Zone Park. Travel by the National Civil Rights Museum and stopto see The Lorraine Motel.

Activity Level: Moderate| ADA ACCESSIBLE: Yes

The Memphis Rock ‘n’ Soul Museum was the first exhibition ever to have been developed by the Smithsonian Institution with another museum. The exhibition tells the story of musical pioneers who overcame racial and socio-economic barriers to create music that would influence American culture and the world. Visit the Memphis Music Hall of Fame. Explore the museum and exhibition which introduces guests to some of the greatest musicians of all time, each who contributed the city’s musical legacy. Enjoy never-before-seen memorabilia, rare video performances and interviews, interactive exhibits, and more.

Activity Level: Moderate | ADA ACCESSIBLE: Yes

Day 12 Cape Girardeau, MO

Cape Girardeau, is truly a hidden gem along the river. Brimming with history, charm, and you can’t forget that unmistakable Midwestern flair. This port has a story to tell, and you can learn all about it as you walk through a series of murals that detail the highs and lows of this small city’s history. Wander through its quaint streets, pop into quirky shops, and walk train tracks that signal Cape Girardeau’s trading influence. At this port, you can get even closer to the waters you’ve been sailing.

The Old Bridge Overlook – an iconic spot offers views that will steal your breath away, as the mighty Mississippi meanders lazily below. Step back in time at the Cape River Heritage Museum, where history comes alive through immersive exhibits and fascinating tales.

Join a local guide on a narrated exploration of Cape Girardeau, a city that began as a small trading post over 200 years ago. Visit Old St. Vincent’s Church and admire its Renaissance architecture, and then Southeast Missouri State University’s Crisp Museum which features fine art exhibitions, Native American artifacts and interpretive regional history displays.

Activity Level: Moderate| ADA ACCESSIBLE: Partial

The Mississippi River Tales Mural is the largest and most dramatic of Cape Girardeau's murals and is located on a portion of the floodwall. Covering nearly 18,000 square feet, this 1,100-foot-long mural features 24 historically-themed panels that vividly portray Cape Girardeau's rich history and heritage. Along the way, descriptive markers provide an explanation of each panel.

Activity Level: High| ADA ACCESSIBLE: No

Day 13 Day of River Cruising

Today isn't just about reaching our destination; it's about embracing the journey itself, especially as we sail along this renowned waterway. Take a moment to head up to the sun desk to view the untouched landscapes and charming little towns hidden along the banks. Keep your eyes out for the magnificent wildlife that calls this majestic river home.

As we cruise along, our onboard expert will treat you to fascinating tales of the native wildlife that inhabit these waters. Today is a day to slow down, to appreciate the beauty that surrounds you, and to let the rhythm of the river soothe your soul.

There are a variety of activities scheduled on board when the ship is underway, which vary depending on the itinerary and scheduled date. Enjoy destination-focused enrichment programs with special guest speakers who present topics related to the region and ports of call, including Art Classes, App-titude Classes (Tech Made Easy), Cooking Demonstrations, Mixology (practice of making great cocktails,) Trivia, Game Shows, and more.

Day 14 St. Louis, MO

As we approach this iconic destination, behold the skyline of St. Louis coming into view against the horizon, a testament to its rich history and energy.

As we cruise closer, take in the sights of this Midwestern metropolis, from its towering arch that pierces the sky to the charming neighborhoods that keep this city moving. Don’t miss out on the regional culinary delights here: gooey butter cake and toasted ravioli.

While we glide along the river, listen as our onboard expert shares St. Louis's storied past, from its role in shaping the nation's history to its vibrant cultural scene. Or perhaps, find a spot on the deck to take in the warm sun and marvel at the beauty of the Mississippi rolling by.

Relive the story of the Native Americans, explorers, pioneers, and rebels who made America possible. Featuring over 200 years of history within six themed exhibit areas, this innovative and interactive museum celebrates America’s pioneering spirit and explains the westward expansion of the U.S., with an emphasis on St. Louis’ role in that era.

Shaped by the inspired design of Finnish-America architect Eero Saarinen, the Gateway Arch monument celebrates the expansion West and the pioneers who made it possible. Since its completion in 1965, millions of visitors have taken a trip to the top to enjoy stunning views. Begin your adventure with our new, interactive pre-boarding exhibits featuring 60s-era animation and Gateway Arch trivia. Then, be transported 630 feet to the top of America’s tallest man-made monument. Or, if you prefer, enjoy the movie Monument to a Dream.

Note: Only available on cruises ending in St. Louis/Alton, as well as on the Complete Mississippi River and Grand Heartland cruises.

Activity Level: Low| ADA ACCESSIBLE: Yes

Explore the most popular exhibits at the Missouri History Museum including “The 1904 World’s Fair: Looking Back at Looking Forward” and “Many Memories: 100 Years on the Stage.” Time will also be allowed for the Seeking St. Louis galleries on display. Self-guided exploration will allow you to view the exhibits at your leisure and give you time to shop.

Note: This excursion is only available on cruises ending in St. Louis/Alton as well as the Complete Mississippi and Grand Heartland.

Activity Level: Low| ADA ACCESSIBLE: Yes

Day 15 Day of River Cruising

As we sail towards the historic city of Hannibal, embrace the beauty of the heartland unfolding before you. Whether you prefer to mingle with fellow guests in one of our lounges, lose yourself in the pages of a captivating book on your private balcony, or join in on one of the many onboard activities, there's something for everyone to enjoy. Don’t miss cocktail hour to share stories with your fellow travelers before sitting down for a dinner carefully curated to represent the river.

There are a variety of activities scheduled on board when the ship is underway, which vary depending on the itinerary and scheduled date. Enjoy destination-focused enrichment programs with special guest speakers who present topics related to the region and ports of call, including Art Classes, App-titude Classes (Tech Made Easy), Cooking Demonstrations, Mixology (practice of making great cocktails,) Trivia, Game Shows, and more.

Day 16 Hannibal, MO

This charming slice of Americana is situated along the river’s shoreline. Here, cobblestone streets relive Mark Twain's boyhood escapades, establishing itself as a literary legacy. Quaint Victorian homes stand sentinel over the riverbanks, their colorful facades reflecting the vibrant character of this historic town. The lives of Twain's beloved characters, Tom Sawyer and Huckleberry Finn, seem to come through the streets, inspiring adventure. From the iconic white picket fence of the Mark Twain Boyhood Home to the quaint charm of the Becky Thatcher House, each corner of Hannibal is adorned with stories waiting to be discovered.

As you arrive in Hannibal, the boyhood home of famous author Mark Twain, relive the author’s experiences that heavily influenced his writings. Visit the actual home that Mark Twain grew up in, which is surrounded by the legendary whitewashed fence of Tom Sawyer. The vivid stories told by Mark Twain come to life at this interactive museum. Visit the Becky Thatcher House, the Huck Finn Home, and the Tom and Huck Statue at the foot of Cardiff Hill. Stop at the Interpretive Center, home to 15 original Normal Rockwell paintings.

Activity Level: Low| ADA Accessibility: Yes

Explore downtown Hannibal on your own. Take time for shopping and strolling through town. Our convenient shuttle will also take you to the following:

Hannibal History Museum - Through interactive exhibits, artifacts, and historic photos, learn the story of Hannibal's remarkable past.

Mark Twain Boyhood Home &Museum - Enjoy a guided exploration of the Mark Twain Boyhood Home and Museum. This is truly a piece of Americana.

Activity Level: Low| ADA Accessibility: Yes

Step back in time and relive the adventures of Mark Twain’s days in Hannibal. Your guide will share the history of Hannibal and will show you sites of historical importance. While on your excursion, visit Rockcliffe Mansion – this American “castle” has a breathtaking view overlooking the Mississippi and is on the National Register of Historic Homes.

Activity Level: Low | ADA Accessible: No

Join Richard Garey as Mark Twain and stroll through the streets of Hannibal, the hometown that inspired Mark Twain’s famous literary novels. Learn about its history through the author’s own words and observations and then enjoy a special performance of “Mark Twain Himself” at the Planter’s Barn Theater.

Activity Level: High| ADA Accessible: Yes

Day 17 Day of River Cruising

Settle into one of our spacious lounges aboard the riverboat, where you can lose yourself in the pages of a captivating book as we continue from Hannibal to Muscatine. Alternatively, find tranquility on the sun deck or your private balcony, where you can relax and immerse yourself in the passing landscapes. Let the calm rock of the river carry you on a journey of serenity and discovery, as each bend reveals a new vista to behold. Whether you're seeking solitude or companionship, there's no better place to unwind and savor the beauty of the heartland than aboard our riverboat.

There are a variety of activities scheduled on board when the ship is underway, which vary depending on the itinerary and scheduled date. Enjoy destination-focused enrichment programs with special guest speakers who present topics related to the region and ports of call, including Art Classes, App-titude Classes (Tech Made Easy), Cooking Demonstrations, Mixology (practice of making great cocktails,) Trivia, Game Shows, and more.

Day 18 Muscatine, IA

Along the meandering banks, Muscatine, stands as a testament to both the tranquility of nature and the resilience of its people. Here, the river's gentle currents carry the voices of the past and the present. In the heart of the city, the Pearl Button Museum pays homage to Muscatine's unique history, while Pine Creek Grist Mill stands as a sentinel to the community's enduring spirit. Wander through quaint streets adorned with historic architecture, where each building tells a tale of days gone by. As the sun dips below the horizon, painting the sky with hues of orange and gold, Muscatine's timeless allure casts a spell, enchanting all who have the pleasure of experiencing its beauty.

Enjoy 18 holes of golf at Geneva Golf & Country Club. History surrounds you at this 123 year old, championship location that is both challenging for the experienced golfer and fair and fun for the beginner. The course is a masterpiece featuring rolling terrain, rambling Geneva Creek, strategically placed bunkers, and three sets of tees that allow the course to be set up for various playing levels. In addition, you will enjoy drinks served on the course and a special take home gift consisting of balls, towel, and divot tool. Activity Level: High / ADA Accessible: No This is a Signature shore excursion and should be reserved in advance. Please call (800) 894-8570 for information.

Explore the area at your leisure with our convenient motorcoach making stops at:

Activity Level: Low / ADA Accessible: Yes

Come visit the lovingly restored Pine Creek Grist Mill, at Wildcat Den State Park, reputed to be the oldest, most complete gristmill between the Mississippi River and the Rocky Mountains. Your friendly and experienced guide will interpret the significance of the 175 year old mill, its original milling equipment, and its picturesque setting. Listen to dramatic stories about the mill’s various owners and watch as the mill’s complex systems of belts and pulleys bring the milling process to life. With the mill being part of Iowa’s state park system, you are sure to enjoy all of nature’s glory.

Activity Level: Moderate / ADA Accessible: No

Day 19 Dubuque, IA

Dubuque proudly boasts its status as one of the oldest settlements west of the Mighty Mississippi, flourishing with a history as rich as the currents that flow by its shores. Experience the world's shortest and steepest scenic railway with a ride on the Fenelon Place Elevator, offering sweeping views of the city and river below.

See the colorful Victorian mansions that dot the landscape, each one a testament to Dubuque's storied past and architectural wonder. And no visit to Dubuque would be complete without exploring the wonders of the National Mississippi River Museum & Aquarium, where the river's vibrant ecosystem comes to life in immersive exhibits and interactive displays.

This convenient shuttle will transport you from the ship to the center of town and back. At your leisure, explore the many districts of downtown Dubuque, including Cable Car Square, the Historic Millwork District, and Historic Old Main District, once a hideaway for notorious gangster Al Capone. Visit the Summer Farmers Market which has been located in the Upper Main district since 1845. Running daily on a continuous loop.

Activity Level: Low| ADA ACCESSIBLE: Yes

Delight in an exploration of some of the highlights of Dubuque. First, stop at Steeple Square Event Center, one of the oldest catholic churches in Dubuque which was renovated into a vibrant community gathering space. Next, arrive at Dubuque Arboretum & Botanical Garden for a guided exploration of the beautiful landscapes. Visit the Convivium Urban Farmstead, a center which celebrates the efforts of local gardeners with onsite cooking and gardening classes as well as a restaurant that serves local produce. Ride the Fenelon Place Elevator, the shortest steepest railway in the United States. Don’t forget the camera, it’s a great opportunity to get a photo of the ship at dock in the Port of Dubuque from above the bluffs.

Activity Level: Moderate | ADA ACCESSIBLE: Yes

Take an entertaining and informative journey along the mighty Mississippi at the National Mississippi River Museum & Aquarium. The museum’s interactive exhibits will give you an inside look at the Mississippi River's past, present, and future. On this guided exploration, learn about the lives of the pioneers, explorers, and artists who once lived along the Mississippi River. Get close to nature, as you make your way through six large aquariums.

Activity Level: Medium| ADA ACCESSIBLE: Yes

Travel to the Field of Dreams Movie Site, built by Universal Studios and known for the famous quote, “If you build it, he will come.” Released in 1989, Field of Dreams, starring Kevin Costner, was a movie that inspired millions and became an Academy Award nominee for “Best Picture of the Year.” Explore this famous site, including the baseball field, the magical corn, and the farm house in which the movie was made. After, visit the gift shop for some take-home movie memorabilia.

Activity Level: Moderate| ADA Accessibility: Yes

Day 20 Day of River Cruising

As you sail from Dubuque to Winona, notice the beauty of the Midwestern shoreline from your private balcony. Let the river inspire you, surrounded by charming towns and serene landscapes. Feel the gentle motion of the water as it guides your journey along this historic route. This experience is not just a voyage, but a moment to stop and look around.

There are a variety of activities scheduled on board when the ship is underway, which vary depending on the itinerary and scheduled date. Enjoy destination-focused enrichment programs with special guest speakers who present topics related to the region and ports of call, including Art Classes, App-titude Classes (Tech Made Easy), Cooking Demonstrations, Mixology (practice of making great cocktails,) Trivia, Game Shows, and more.

Day 21 Winona, MN

Among the rolling bluffs , Winona, Minnesota, exudes a quiet grace. Its quaint streets, lined with Victorian-era architecture, stand as a testament to a bygone era, while the river's gentle currents weave tales of time immemorial. Winona's artistic soul shines through in its vibrant cultural scene. Explore the city's history at the Minnesota Marine Art Museum, where masterpieces inspired by the river's majestic beauty come to life. Or, wander through rolling fields of prairie flowers. As the sun sets over the horizon, casting a golden glow over the bluffs and river below, Winona's timeless charm stays with all who wander its scenic shores.

Enjoy a guided, in-depth exploration of the historic and intriguing sites around greater Winona. Stops include the Winona County History Center, Minnesota Marine Art Museum, Garvin Heights lookout with amazing views of this stretch of the Mississippi River Valley, and more.

Activity Level: Low| ADA Accessibility: Yes

Take a guided walk through Winona's historic downtown to admire great architecture, hear surprising stories, and play a fun game or two.

Activity Level: Low| ADA Accessibility: Yes

Running on a continuous loop, this guided exploration shuttle takes you from the ship to Winona's hot spots including history and art museums, historic places with beautiful architecture and stained glass, and to the heart of Downtown so you can shop, eat, and stroll at your leisure.

Activity Level: Low| ADA Accessibility: Yes

This narrated Winona boat exploration not only entertains but educates about the famed waterway, the history of Winona and its relation to the Mississippi River. Bring your camera and binoculars to view local wildlife like eagles, deer, turtles, snakes, and beaver on this mesmerizing river cruise.

Activity Level: Low

Enter the quiet and rich environment of Pool 6 of the Mississippi River and observe wildlife up close within the forested backwaters. On a sit-on-top kayak or canoe, with a partner or on your own, paddle along the smooth water, stopping for a refreshment along the way. A portion of each excursion cost goes towards reclamation efforts in the surrounding Prairie Island Park area.

This is a Signature shore excursion and should be reserved in advance. Please call (800) 894-8570 for information.

Activity Level: moderate |ADA Accessibilty: No

Day 22 Red Wing, MN

Overlooking the northern riverbanks, Red Wing has been a muse for craftsmen and artisans for over 150 years. Its beauty, with its extending cliffs and sweeping river views, has inspired countless works of art and creativity. Experience the city's vibrant cultural scene at the historic Sheldon Performing Arts Theatre, where world-class performances await. Or, immerse yourself in the natural escape of one of Red Wing's 38 parks, each offering its own unique charm, from the tranquil riverside trails of Colvill Park to the thick greenery of Barn Bluff. Whether you're seeking artistic inspiration or outdoor adventure, Red Wing invites you to discover the magic that has captivated hearts for generations.

There's no better way to experience the capital city of St. Paul than on this carefully-curated excursion. Saint Paul, though the state capital, moves at a slower pace and has prided itself on architectural preservation, boasting some of the Midwest's last remaining Victorian Romanesque blocks. Led by our engaging guide, explore all this beautiful city has to offer as well as a brief stop at the Minnehaha Falls.

Note: Only available on cruises ending in St. Paul/Red Wing.

Activity Level: Low| ADA Accessibility: Yes

Visit the National Eagle Center, offering additional up close viewing of non-releasable bald and golden eagles. Learn about the ecology, biology, and natural history of these magnificent creatures.

Activity Level: Low| ADA ACCESSIBLE: Yes

Travel back in time as you explore the beautiful city of Red Wing. Led by our local expert guide, view some of the most impressive Victorian homes of the period as well as the historic St. James Hotel. Visit the Pottery Museum of Red Wing and admire the numerous true vintage pieces on site such as stoneware, dinnerware, folk art, and more! Stop at the Sheldon Theatre, among the oldest operating theatres in Minnesota and host to thousands of large national touring acts, international artists, and local performers alike.

Activity Level: Low| ADA Accessibility: Yes

Explore the highlights of Red Wing on this convenient shuttle to:

Activity Level: Low / ADA Accessible: Yes

Day 23 St. Paul, MN

Concluding your riverboat adventure on the Mighty Mississippi in St. Paul promises excitement and exploration. History buffs can delve into the past with a walking excursion along Summit Avenue, showcasing stunning historic mansions from the late 1800s. Take it slow at enchanting art galleries, world-class museums, and captivating stage performances that St. Paul has to offer, igniting your imagination at every turn. As the day winds down, don't miss the opportunity to visit Mounds Park, where a breathtaking panoramic view of the city awaits, providing the perfect finale to your unforgettable journey.

We’ve made it. The end of this Mississippi Odessey. And what an adventure it has been. From the sounds of Memphis to the metaphors forged in Hannibal, you’ve seen it all. As you head home, American Cruise Lines extends a warm gratitude for exploring with us. We hope to see you on the river soon.
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